Rapaport R, Petersen B, Skuza K A, Heim M, Goldstein S
Department of Pediatrics, UMDNJ-New Jersey Medical School.
Clin Pediatr (Phila). 1991 Jan;30(1):22-7. doi: 10.1177/000992289103000104.
Immune functions, including cell surface markers, interleukin-2 receptor levels and responses of lymphocytes to mitogenic stimulation were evaluated in seven growth hormone deficient children ages 4-15 years, during treatment with biosynthetically derived human growth hormone. Treatment resulted in a decrease in % B cells and in % T total cells and also decreases in most individual patients' mitogen responses and interleukin-2 receptor levels. Most of the changes noted were transient and similar to those previously demonstrated during pituitary-derived human growth hormone treatment. Although not resulting in overt clinical manifestations in our patients, we think that potential interactions between growth hormone and immune functions need to be considered by physicians treating children with growth hormone.
对7名年龄在4至15岁的生长激素缺乏儿童在接受生物合成的人生长激素治疗期间的免疫功能进行了评估，包括细胞表面标志物、白细胞介素-2受体水平以及淋巴细胞对有丝分裂原刺激的反应。治疗导致B细胞百分比和总T细胞百分比下降，大多数个体患者的有丝分裂原反应和白细胞介素-2受体水平也下降。所观察到的大多数变化是短暂的，与先前垂体来源的人生长激素治疗期间所显示的变化相似。虽然在我们的患者中未导致明显的临床表现，但我们认为治疗生长激素缺乏儿童的医生需要考虑生长激素与免疫功能之间的潜在相互作用。
