Petersen B H, Rapaport R, Henry D P, Huseman C, Moore W V
Lilly Research Laboratories, Eli Lilly Co., Indianapolis, Indiana 46202.
J Clin Endocrinol Metab. 1990 Jun;70(6):1756-60. doi: 10.1210/jcem-70-6-1756.
GH influences the immune response. The mechanism is not known; however, the presence of receptors for GH on human lymphocytes as well as its ability to influence and modulate immune responses in animals suggest an association between GH and immune function in man. We evaluated the effect of recombinantly derived natural sequence human GH (hGH) on lymphocyte surface antigen expression, response to mitogenic stimulation, expression of interleukin-1 receptors, and production of anti-hGH antibodies in GH-deficient children. The only observed changes were a decrease in the percentage of B-cells and a transient increased reactivity to phytohemagglutinin stimulation. It appears from the results of our studies that the administration of hGH has a selective effect on lymphocyte immune function; however, we cannot eliminate a role for hGH in the initiation or regulation of antigen-mediated immune responses.
生长激素影响免疫反应。其机制尚不清楚；然而，人类淋巴细胞上存在生长激素受体，以及它影响和调节动物免疫反应的能力，提示生长激素与人类免疫功能之间存在关联。我们评估了重组衍生的天然序列人生长激素（hGH）对生长激素缺乏儿童淋巴细胞表面抗原表达、对有丝分裂原刺激的反应、白细胞介素-1受体表达以及抗hGH抗体产生的影响。唯一观察到的变化是B细胞百分比降低以及对植物血凝素刺激的反应性短暂增加。从我们的研究结果来看，hGH的给药对淋巴细胞免疫功能有选择性作用；然而，我们不能排除hGH在抗原介导的免疫反应的启动或调节中的作用。
