Abbassi V, Bellanti J A
Pediatr Res. 1985 Mar;19(3):299-301. doi: 10.1203/00006450-198503000-00009.
To delineate the role of growth hormone (GH) in the development and function of the immune system, immunological parameters including quantitative immunoglobulins, T and B lymphocytes, phytohemagglutinin lymphoproliferative response and delayed hypersensitivity skin tests were studied in nine GH-deficient children prior to GH therapy and at 2 months and 9 to 12 months following therapy. The phytohemagglutinin response (74.1 +/- 37.6, mean +/- SD), and the T rosette (58.3% +/- 9.4), B rosette (21.1% +/- 6.1), IgG (810 +/- 241 mg/dl), (IgA 140 +/- 85), and IgM (176 +/- 70) levels in GH-deficient children were comparable to age adjusted values in normal children. Following GH therapy the phytohemagglutinin response increased significantly at 9 to 12 months post-therapy, 123.2 +/- 51.9 versus 74.1 +/- 37.6, p less than 0.05. T and B rosettes, immunoglobulin concentrations, and hypersensitivity skin tests were not affected by GH therapy. Although an effect of GH was not demonstrable by these studies, a positive role of GH cannot be entirely excluded since total GH deficiency did not exist in all children.
为了阐明生长激素（GH）在免疫系统发育和功能中的作用，我们对9名生长激素缺乏儿童在接受GH治疗前、治疗后2个月以及治疗后9至12个月的免疫参数进行了研究，这些参数包括定量免疫球蛋白、T和B淋巴细胞、植物血凝素淋巴细胞增殖反应以及迟发型超敏皮肤试验。生长激素缺乏儿童的植物血凝素反应（74.1±37.6，平均值±标准差）、T玫瑰花结（58.3%±9.4）、B玫瑰花结（21.1%±6.1）、IgG（810±241mg/dl）、IgA（140±85）和IgM（176±70）水平与正常儿童经年龄校正后的数值相当。GH治疗后，植物血凝素反应在治疗后9至12个月显著增加，从74.1±37.6增至123.2±51.9，p<0.05。T和B玫瑰花结、免疫球蛋白浓度以及超敏皮肤试验均未受GH治疗的影响。尽管这些研究未证明GH有作用，但由于并非所有儿童都存在完全性GH缺乏，因此不能完全排除GH的积极作用。
