New York, N.Y. From the Division of Plastic Surgery, Department of Surgery, New York Presbyterian Hospital, Columbia University College of Physicians and Surgeons, and Weill Cornell Medical College.
Plast Reconstr Surg. 2009 Dec;124(6):2072-2075. doi: 10.1097/PRS.0b013e3181bcefc4.
Craniosynostosis alters the normal growth of the infant skull and can influence intracranial pressure and intracranial volume. The purpose of this study was to measure intracranial volumes in a large series of healthy children to serve as a reference for further studies exploring the impact of craniosynostosis and vault remodeling on intracranial growth.
A total of 123 children were included in this study from a retrospective review of pediatric emergency room visits for evaluation of head trauma where a head computed tomography scan was performed. Intracranial volumes were obtained using a semiautomated image segmentation technique and volume-rendering software.
Volume measurements were obtained and plotted against age, and a best fit curve approximation was derived. In this study of healthy children, intracranial volume doubled by 9 months of age and tripled by 6 years of age.
This large study contributes to the existing data demonstrating intracranial volumes in healthy children up to 6 years of age. These data can be used by clinicians as a reference in the assessment of a child presenting with cranial dysmorphology.
颅缝早闭会改变婴儿颅骨的正常生长，从而影响颅内压和颅内体积。本研究的目的是测量大量健康儿童的颅内体积，为进一步研究颅缝早闭和颅腔重塑对颅内生长的影响提供参考。
本研究回顾性分析了因头部外伤就诊于儿科急诊的患儿，共纳入 123 名患儿。所有患儿均行头部 CT 扫描。采用半自动图像分割技术和容积再现软件获得颅内体积。
获得了体积测量值并与年龄进行了对比，得出了最佳拟合曲线近似值。在这项针对健康儿童的研究中，颅内体积在 9 个月时增加了一倍，在 6 岁时增加了两倍。
这项大型研究提供了健康儿童到 6 岁的颅内体积的现有数据。这些数据可用于临床医生评估具有颅面畸形的儿童。
