HIV 相关性隐球菌性脑膜炎的软脑膜颗粒和脑的组织病理学：与脑脊液压力的相关性。
Histopathology of the arachnoid granulations and brain in HIV-associated cryptococcal meningitis: correlation with cerebrospinal fluid pressure.
机构信息
Infectious Diseases Unit, GF Jooste Hospital, South Africa.
出版信息
AIDS. 2010 Jan 28;24(3):405-10. doi: 10.1097/QAD.0b013e328333c005.
Abstract
OBJECTIVE
To investigate the histopathology of the arachnoid granulations in patients with HIV-associated cryptococcal meningitis and correlate the findings with clinical data, in particular cerebrospinal fluid (CSF) opening pressure.
DESIGN
Case series.
METHODS
Postmortems were requested on patients dying during initial hospitalization with HIV-associated cryptococcal meningitis.
RESULTS
Five postmortems were performed. Large numbers of cryptococcal cells were seen within the arachnoid granulations. The number of fungal cells correlated with CSF pressure. Inflammatory cell infiltrates and disruption of the normal architecture of the granulations were also observed.
CONCLUSION
The study provides the first direct evidence supporting the obstruction to CSF reabsorption at the level of the arachnoid granulations as the main mechanism underlying the development of raised CSF pressure in HIV-associated cryptococcal meningitis.
摘要
目的
研究人类免疫缺陷病毒（HIV）相关隐球菌性脑膜炎患者蛛网膜颗粒的组织病理学变化，并将其发现与临床数据，特别是脑脊液（CSF）开放压力相关联。
设计
病例系列。
方法
对在初次住院期间死于 HIV 相关隐球菌性脑膜炎的患者进行尸检。
结果
进行了 5 例尸检。大量隐球菌细胞可见于蛛网膜颗粒内。真菌细胞的数量与 CSF 压力相关。还观察到炎症细胞浸润和蛛网膜颗粒正常结构的破坏。
结论
该研究提供了第一个直接证据，支持 CSF 在蛛网膜颗粒水平重吸收受阻是 HIV 相关隐球菌性脑膜炎中 CSF 压力升高的主要机制。
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