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体外生命支持作为肺移植的桥梁。

Extracorporeal support as a bridge to lung transplantation.

机构信息

Department of Cardiothoracic, Transplant, and Vascular Surgery, Hannover Medical School, Hannover, Germany.

出版信息

Curr Opin Crit Care. 2010 Feb;16(1):69-73. doi: 10.1097/MCC.0b013e3283353ce0.

Abstract

PURPOSE OF REVIEW

Allocation of grafts for lung transplantation has been directed in many countries to patients in life-threatening conditions. Advances in technology for extracorporeal devices led to new concepts and increased use for bridging to lung transplantation. Taking these two developments into account, it seems that bridging technologies are used more frequently around the world.

RECENT FINDINGS

The durability of extracorporeal devices for some weeks was described in many institutional and case reports. The change in technology seems to open a new era of possibilities. Use of this new technology not only in bridge to transplant but also as a bridge to recovery in acute respiratory distress syndrome patients was published most recently. Current and future use of extracorporeal gas exchange as an alternative to mechanical ventilation appears in the literature. Use of low resistance membranes in patients with pulmonary hypertension was described as a new therapeutical option.

SUMMARY

Bridge to lung transplantation is of increasing importance with new allocation systems and the increasing demand. New extracorporeal technologies address this demand with reliable function for some weeks. But these developments also raise ethical questions of how to use these new tools wisely individually and also collectively for the field of lung transplantation.

摘要

目的综述

在许多国家,肺移植的供体分配都针对生命垂危的患者。体外设备技术的进步带来了新概念,增加了用于肺移植桥接的应用。考虑到这两个发展,似乎世界各地都更频繁地使用桥接技术。

最近的发现

许多机构和案例报告描述了体外设备数周的耐用性。技术的变革似乎开辟了一个新的可能性时代。最近发表了这项新技术不仅用于移植桥接,还用于急性呼吸窘迫综合征患者的恢复桥接的应用。体外气体交换作为机械通气替代的当前和未来应用出现在文献中。在肺动脉高压患者中使用低阻力膜被描述为一种新的治疗选择。

总结

随着新的分配系统和需求的增加,肺移植桥接的重要性日益增加。新的体外技术以数周可靠的功能满足了这一需求。但这些发展也引发了一些伦理问题,即如何明智地单独使用这些新工具,以及如何集体为肺移植领域使用这些新工具。

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