Division of Cardiology, Department of Medicine, QEII Health Sciences Centre, Dalhousie University, Halifax, Nova Scotia, Canada.
Med Sci Sports Exerc. 2010 Apr;42(4):665-71. doi: 10.1249/MSS.0b013e3181bdc685.
To determine the independent and interactive associations among body mass index (BMI), physical activity (PA), and health-related quality of life (HRQoL) in breast, prostate, colorectal, bladder, uterine, and skin melanoma cancer survivors.
A total of 3241 cancer survivors completed a national cross-sectional survey that included PA questions and the RAND-36 Health Status Inventory.
Compared with healthy-weight survivors, obese breast, prostate, bladder, and skin melanoma cancer survivors were significantly less likely to meet the PA guideline. Furthermore, healthy-weight and/or overweight breast, prostate, colorectal, uterine cancer, and skin melanoma survivors reported significantly better physical functioning compared with their obese counterparts, whereas overweight colorectal cancer survivors reported significantly better mental health compared with obese survivors. Finally, hierarchical linear regressions showed that none of the BMI × PA interactions was significant for the physical or mental component composite scores across the cancer types.
The percentage of cancer survivors meeting the American Cancer Society's PA guideline seems to vary by weight status in breast, prostate, bladder, and skin melanoma cancer survivors. In addition, BMI and PA have independent associations with HRQoL; however, the interactive association of BMI and PA on HRQoL was negligible. Clarifying the relationship between BMI and PA across different cancer types will help identify potential target groups for future PA interventions that will help ameliorate the negative side effects of cancer and improve HRQoL.
确定体重指数（BMI）、身体活动（PA）与乳腺癌、前列腺癌、结直肠癌、膀胱癌、子宫癌和皮肤黑色素瘤幸存者健康相关生活质量（HRQoL）之间的独立和交互关联。
共有 3241 名癌症幸存者完成了一项全国性的横断面调查，该调查包括 PA 问题和 RAND-36 健康状况量表。
与健康体重幸存者相比，肥胖的乳腺癌、前列腺癌、膀胱癌和皮肤黑色素瘤癌症幸存者明显不太可能符合 PA 指南。此外，与肥胖者相比，健康体重和/或超重的乳腺癌、前列腺癌、结直肠癌、子宫癌和皮肤黑色素瘤幸存者报告的身体机能明显更好，而超重的结直肠癌幸存者报告的心理健康明显好于肥胖幸存者。最后，分层线性回归显示，在所有癌症类型中，BMI 和 PA 的相互作用对身体或心理综合评分均无显著影响。
符合美国癌症协会 PA 指南的癌症幸存者比例似乎因乳腺癌、前列腺癌、膀胱癌和皮肤黑色素瘤幸存者的体重状况而有所不同。此外，BMI 和 PA 与 HRQoL 有独立的关联；然而，BMI 和 PA 对 HRQoL 的交互关联可以忽略不计。阐明不同癌症类型之间 BMI 和 PA 的关系将有助于确定未来 PA 干预的潜在目标人群，以帮助减轻癌症的负面副作用并改善 HRQoL。
