Shvetsova T P, Lomanova G A, Dzagurov S G, Shalunova N V, Andronova A V
Genetika. 1977;13(8):1373-7.
Mutagenic effect of Kilham virus on the frequency of chromosome aberrations in the cells of primary and continous rat embryo cultures and the modification effect of cadmium salt on the mutagenic potential of this virus was studied. The frequency of chromosome aberrations increased in the primary rat embryo culture after Kilham virus enfection. Rat embryo culture chronically infected with Kilham virus did not differ from control continuous cells in the frequency level of chromosome aberrations. Isertion of cadmium in the process of cultivation increased the mutagenic effect of kilham virus in the primary rat embryo culture.
研究了基尔汉姆病毒对原代和连续传代大鼠胚胎培养细胞染色体畸变频率的诱变作用，以及镉盐对该病毒诱变潜力的修饰作用。基尔汉姆病毒感染后，原代大鼠胚胎培养物中染色体畸变频率增加。长期感染基尔汉姆病毒的大鼠胚胎培养物在染色体畸变频率水平上与对照连续细胞没有差异。在培养过程中加入镉会增加基尔汉姆病毒在原代大鼠胚胎培养物中的诱变作用。
