Darrigrand A A, Singh S B, Lang C M
Am J Vet Res. 1984 Jan;45(1):200-2.
Effects of Kilham rat virus (KRV) on selected aspects of the immune response of 2 strains of laboratory rats were studied. The Brown Norway rat and Wistar Furth rat were infected with KRV and serum antibody and interferon values and cytotoxic activity of natural killer cells were determined to assess the virus' effect on the rat's immune systems. Antibody values to the virus were increased in both strains after viral inoculation, and total antibody values were comparable in the 2 rat strains. Natural cytotoxicity was increased in Brown Norway rats 3 to 4 days after inoculation in contrast to a distinct depression for a period of 10 days in the Wistar Furth strain. Serum interferon was not measurable in either strain of rat. Seemingly, there is a distinct immune response to KRV in each rat strain and the cytotoxic activity response differs in these 2 strains of rats.
研究了基尔汉姆大鼠病毒（KRV）对2种实验大鼠品系免疫反应某些方面的影响。将棕色挪威大鼠和威斯塔·弗思大鼠感染KRV，并测定血清抗体、干扰素值以及自然杀伤细胞的细胞毒性活性，以评估该病毒对大鼠免疫系统的影响。病毒接种后，两种品系大鼠针对该病毒的抗体值均升高，且两种大鼠品系的总抗体值相当。接种后3至4天，棕色挪威大鼠的自然细胞毒性增强，相比之下，威斯塔·弗思品系在10天内细胞毒性明显降低。两种大鼠品系的血清干扰素均无法检测到。显然，每种大鼠品系对KRV都有明显的免疫反应，且这两种大鼠品系的细胞毒性活性反应有所不同。
