Félix L, Lantuejoul S, Jankowski A, Ferretti G
Clinique Universitaire de Radiologie et Imagerie Médicale, Pôle d'Imagerie, CHU de Grenoble, France.
J Radiol. 2009 Nov;90(11 Pt 2):1869-92. doi: 10.1016/s0221-0363(09)73289-5.
Localized ground-glass opacities (GGOs) have been recently individualized and account for between 2.9% and 19% of all pulmonary nodules detected in high-risk patients included in CT screening series for lung cancer. These opacities, nodular, lobular or flat, correspond to benign lesions (localised infectious and inflammatory diseases, focal interstitial fibrosis, and atypical alveolar hyperplasia) or malignant lesions (bronchioloalveolar carcinoma, early-stage adenocarcinoma and sometimes metastases). Localized GGOs are more likely to be malignant than solid nodules and prognosis is related to the percentage of the ground-glass component. However, doubling time of pure localized malignant GGOs is longer than mixed localized malignant GGOs and even longer than the doubling time of solid malignant nodules. Therefore, localized GGOs warrant a dedicated diagnostic workup.
局限性磨玻璃影（GGOs）最近已被个体化，在肺癌CT筛查系列纳入的高危患者中检测到的所有肺结节中占2.9%至19%。这些磨玻璃影呈结节状、小叶状或扁平状，对应良性病变（局限性感染性和炎症性疾病、局灶性间质纤维化以及非典型肺泡增生）或恶性病变（细支气管肺泡癌、早期腺癌，有时还有转移瘤）。局限性GGOs比实性结节更有可能是恶性的，预后与磨玻璃成分的百分比有关。然而，单纯局限性恶性GGOs的倍增时间比混合性局限性恶性GGOs更长，甚至比实性恶性结节的倍增时间还要长。因此，局限性GGOs需要进行专门的诊断检查。
