职业性即刻型哮喘和鼻炎与铑盐有关。
Occupational immediate-type asthma and rhinitis due to rhodium salts.
机构信息
Research Institute of Occupational Medicine, German Social Accident Insurance (BGFA), Ruhr University, Bürkle-de-la-Camp-Platz 1, Bochum, Germany.
出版信息
Am J Ind Med. 2010 Jan;53(1):42-6. doi: 10.1002/ajim.20786.
BACKGROUND
Whereas platinum salts are well known occupational allergens, rhodium salts have not been identified as inhalative sensitizing substances.
METHODS
A 27-year-old atopic operator of an electroplating plant developed work-related shortness of breath and runny nose with sneezing after exposure to rhodium salts. Quantitative skin prick tests (SPT) and bronchial challenge tests with a dosimeter protocol were performed with quadrupling doses of the sodium chloride salts of rhodium (Na(3)RhCl(6)) and platinum (Na(2)PtCl(6)).
RESULTS
The patient showed positive SPT reactions and positive bronchial immediate-type reactions with rhodium and platinum salts. Sensitivity to rhodium salt was much higher than to platinum salt; the molar concentrations differed by a factor of 256 in SPT and a factor of 16 in bronchial challenges.
CONCLUSIONS
Rhodium salts should be considered as occupational immediate-type allergens.
背景
尽管众所周知，铂盐是职业性过敏原，但铑盐尚未被确定为吸入性致敏物质。
方法
一名 27 岁的电镀厂过敏性作业员在接触铑盐后出现与工作相关的呼吸急促和流鼻涕、打喷嚏。使用铑（Na3RhCl6）和铂（Na2PtCl6）的氯化钠盐进行了定量皮肤点刺试验（SPT）和支气管挑战试验，并采用倍增剂量方案。
结果
患者对铑盐和铂盐均表现出阳性 SPT 反应和阳性支气管即刻型反应。对铑盐的敏感性明显高于对铂盐；在 SPT 中，摩尔浓度差异为 256 倍，在支气管挑战中差异为 16 倍。
结论
铑盐应被视为职业性即刻型过敏原。
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