Karakousis C P, Emrich L J, Rao U, Khalil M
Department of Surgical Oncology, Roswell Park Memorial Institute, Buffalo, New York 14263.
Eur J Surg Oncol. 1991 Feb;17(1):71-80.
One hundred and seventy-one consecutive patients with soft tissue sarcomas were treated in the period 1977-1986. Of 144 patients with extremity sarcomas, only eight (6%) were managed with amputation. The overall estimated 5-year survival rate is 64%, and that for patients with extremity tumors is 71%. The 5-year local recurrence rate in extremity sarcomas was 6% for patients with minimum surgical margins 2 cm or greater and no further local therapy, and 6% for those with narrower surgical margins and adjuvant postoperative radiation; 80 patients (56%) were in the former group and 64 (44%) in the latter. With a selective combination of modalities, limb salvage can now be practiced in 94% of the patients with acceptable local control and survival rates.
1977年至1986年期间，对171例连续性软组织肉瘤患者进行了治疗。在144例肢体肉瘤患者中，仅8例（6%）接受了截肢治疗。总体估计5年生存率为64%，肢体肿瘤患者的5年生存率为71%。对于手术切缘至少2厘米或更宽且未接受进一步局部治疗的肢体肉瘤患者，5年局部复发率为6%；对于手术切缘较窄且术后接受辅助放疗的患者，5年局部复发率也为6%；前一组有80例患者（56%），后一组有64例患者（44%）。通过选择性的联合治疗方式，现在94%的患者能够实施保肢手术，且局部控制率和生存率均可接受。
