Karakousis C P, Emrich L J, Rao U, Khalil M
Surgical Oncology Department, Roswell Park Memorial Institute, Buffalo, NY 14263.
Semin Surg Oncol. 1988;4(1):78-81. doi: 10.1002/ssu.2980040115.
One hundred fifty-two consecutive patients with soft tissue sarcomas were operated in the period 1977 through 1985. Eighty-seven patients with minimum resection margin of 2 cm or greater had no further local therapy, whereas 65 patients with minimum margin less than 2 cm had adjuvant postoperative radiation. Of 121 patients with extremity sarcomas, only 5 (4%) were managed with amputation. The overall 5-year survival rate is 58%, and for patients with extremity tumors, 67%. The 5-year local recurrence rate in extremity sarcomas was 10% for patients with minimum surgical margins 2 cm or greater and no further local therapy, and 6% for those with lesser surgical margins and adjuvant postoperative radiation. With selective combination of modalities limb salvage can now be practiced in 96% of the patients with acceptable local control and survival rates.
1977年至1985年期间，对152例连续性软组织肉瘤患者进行了手术。87例最小切缘为2厘米或更大的患者未接受进一步的局部治疗，而65例最小切缘小于2厘米的患者术后接受了辅助放疗。在121例肢体肉瘤患者中，仅5例（4%）接受了截肢治疗。总体5年生存率为58%，肢体肿瘤患者为67%。对于最小手术切缘为2厘米或更大且未接受进一步局部治疗的肢体肉瘤患者，5年局部复发率为10%，而手术切缘较小且术后接受辅助放疗的患者为6%。通过选择性联合治疗方式，现在96%的患者可以实施保肢手术，且局部控制率和生存率均可接受。
