Zhao Jun-Zhao, Chen Xia, Wang Pei-Yu, Zhou Wei, Lin Jin-Ju, Zhang Wei, Huang Xue-Feng, Lin Wen-Qin, Yang Hai-Yan, Chen Ya
Reproductive Medicine Center, First Affiliated Hospital of Wenzhou Medical College, Wenzhou, China.
Zhonghua Fu Chan Ke Za Zhi. 2009 Jun;44(6):409-12.
To investigate pregnancy outcome of infertility women with polycystic ovary syndrome (PCOS) treated by in vitro maturation (IVM) of immature oocytes.
From Nov. 2003 to Oct. 2007, medical documents of 118 women with PCOS underwent 140 IVM treatment cycles in Reproductive Medical Center of First Affiliated Hospital of Wenzhou Medical College were collected. Follow up of 62 pregnancies were performed by prenatal examination in hospital or telephone query to record perinatal monitoring and pregnancy outcome.
There are 62 pregnant women including 5 biochemical pregnancies and 57 clinical pregnancies obtained in 140 transferred cycles, resulting in the pregnancy rate of 40.7% (57/140). The rates of singleton pregnancies, twin pregnancies and triplet pregnancies were 61.4% (35/57), 29.8% (17/57) and 5.3% (3/57), respectively. The rate of ectopic pregnancy was 3.5% (2/57). Seven (7/57, 12.3%) women underwent early abortion during 7 -14 weeks of pregnancy, and 1 case (1/57, 1.75%) with premature rupture of membranes occurred at 22 gestational week. One woman with twin pregnancy spontaneously reduced to singleton at 8 gestational weeks. Totally, the rate of pregnancy complications was 26.3% (15/57) including premature rupture of membranes (1 case), placenta previa (1 case), hypertensive disorder (1 case), preterm delivery (10 cases) and gestational diabetes mellitus (2 cases). Until now 47 women gave birth to 65 infants including 29 singleton infants and 18 twins. One female preterm neonate died after 6 days' delivery due to pneumonia, no malformation was observed on the other neonates. 21.3% (10/47) of deliveries were premature,76.6% (36/47) of deliveries were full-term, 2.1% (1/47) of deliveries were postterm. The mean birth weight was 2972 gram. The rate of infants with low weight was 26.2% (17/65).
A relatively high clinical pregnancy rate has been achieved, the rates of early abortion, ectopic pregnancy, pregnancy complications, perinatal mortality, and neonatal malformation occurring after the treatment of IVM in women with PCOS are not mounting. However, the relative high rates of multiple pregnancies, low birth weight and preterm labor were increased.
探讨未成熟卵母细胞体外成熟（IVM）治疗多囊卵巢综合征（PCOS）不孕妇女的妊娠结局。
收集2003年11月至2007年10月在温州医学院附属第一医院生殖医学中心接受140个IVM治疗周期的118例PCOS妇女的病历资料。通过住院产前检查或电话随访62例妊娠情况，记录围产期监测及妊娠结局。
140个移植周期中有62例妊娠妇女，其中生化妊娠5例，临床妊娠57例，妊娠率为40.7%（57/140）。单胎妊娠、双胎妊娠和三胎妊娠率分别为61.4%（35/57）、29.8%（17/57）和5.3%（3/57）。异位妊娠率为3.5%（2/57）。7例（7/57，12.3%）妇女在妊娠7 - 14周发生早期流产，1例（1/57，1.75%）在孕22周发生胎膜早破。1例双胎妊娠妇女在孕8周时自然减为单胎。妊娠并发症发生率为26.3%（15/57），包括胎膜早破（例）,前置胎盘（1例）,高血压疾病（1例）,早产（10例）和妊娠期糖尿病（2例）。目前47例妇女分娩65例婴儿，其中单胎29例，双胎18例。1例早产女婴出生6天后因肺炎死亡，其他新生儿未见畸形。21.3%（10/47）的分娩为早产，76.6%（(36/47)的分娩为足月产，2.1%（1/47）的分娩为过期产。平均出生体重为2972克。低体重儿发生率为26.2%（17/65）。
IVM治疗PCOS妇女取得了较高的临床妊娠率，治疗后早期流产、异位妊娠、妊娠并发症、围产儿死亡率及新生儿畸形发生率未增加。然而，多胎妊娠、低体重儿及早产发生率相对升高。
