Lewis 碱导向的 2-吡喃酮和炔基铝试剂的环加成反应。
Lewis base directed cycloaddition reactions of 2-pyrones and alkynylaluminum reagents.
机构信息
Department of Chemistry, University of Sheffield, Brook Hill, Sheffield, S3 7HF, UK.
出版信息
Org Lett. 2013 Aug 16;15(16):4222-5. doi: 10.1021/ol401952k. Epub 2013 Aug 5.
Abstract
In situ generated alkynylaluminum reagents have been utilized in a [4 + 2] cycloaddition with 2-pyrones bearing a Lewis basic donor. The reactions proceed at or below room temperature and with complete regiocontrol. This one-pot method affords diversely substituted aromatic compounds under very mild conditions.
摘要
原位生成的炔基铝试剂已被用于带有路易斯碱性给体的 2-吡喃酮的 [4 + 2] 环加成反应。反应在室温或更低温度下进行，且具有完全的区域选择性。这种一锅法在非常温和的条件下可得到各种取代的芳香族化合物。
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