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Lewis 碱导向的 2-吡喃酮和炔基铝试剂的环加成反应。

Lewis base directed cycloaddition reactions of 2-pyrones and alkynylaluminum reagents.

机构信息

Department of Chemistry, University of Sheffield, Brook Hill, Sheffield, S3 7HF, UK.

出版信息

Org Lett. 2013 Aug 16;15(16):4222-5. doi: 10.1021/ol401952k. Epub 2013 Aug 5.

DOI:10.1021/ol401952k
PMID:23915340
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3766945/
Abstract

In situ generated alkynylaluminum reagents have been utilized in a [4 + 2] cycloaddition with 2-pyrones bearing a Lewis basic donor. The reactions proceed at or below room temperature and with complete regiocontrol. This one-pot method affords diversely substituted aromatic compounds under very mild conditions.

摘要

原位生成的炔基铝试剂已被用于带有路易斯碱性给体的 2-吡喃酮的 [4 + 2] 环加成反应。反应在室温或更低温度下进行，且具有完全的区域选择性。这种一锅法在非常温和的条件下可得到各种取代的芳香族化合物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f240/3766945/d0da8db6a42e/ol-2013-01952k_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f240/3766945/6794f3d359cc/ol-2013-01952k_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f240/3766945/4233b3a35e74/ol-2013-01952k_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f240/3766945/b5f1203acb11/ol-2013-01952k_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f240/3766945/d0da8db6a42e/ol-2013-01952k_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f240/3766945/6794f3d359cc/ol-2013-01952k_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f240/3766945/4233b3a35e74/ol-2013-01952k_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f240/3766945/b5f1203acb11/ol-2013-01952k_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f240/3766945/d0da8db6a42e/ol-2013-01952k_0004.jpg

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