Institute of Human Nutrition, School of Medicine, University of Southampton, Southampton General Hospital, Southampton, United Kingdom.
Int Rev Immunol. 2009;28(6):506-34. doi: 10.3109/08830180903197480.
Fatty acids may influence immune function through a variety of mechanisms; many of these are associated with changes in fatty acid composition of immune cell membranes. Eicosanoids produced from arachidonic acid have roles in inflammation and immunity. Increased membrane content of n-3 fatty acids results in a changed pattern of production of eicosanoids, resolvins, and cytokines. Changing the fatty acid composition of immune cells also affects T cell reactivity and antigen presentation. Little attention has been paid to the influence of fatty acids on the gut-associated lymphoid tissue. However, there has been considerable interest in fatty acids and gut inflammation.
脂肪酸可能通过多种机制影响免疫功能；其中许多与免疫细胞膜脂肪酸组成的变化有关。花生四烯酸产生的类二十烷酸在炎症和免疫中发挥作用。n-3 脂肪酸的膜含量增加导致类二十烷酸、 resolvins 和细胞因子的产生模式发生变化。改变免疫细胞的脂肪酸组成也会影响 T 细胞反应性和抗原呈递。人们对脂肪酸对肠道相关淋巴组织的影响关注甚少。然而，人们对脂肪酸和肠道炎症非常感兴趣。
