[O6-甲基鸟嘌呤-DNA甲基转移酶单核苷酸多态性对非霍奇金淋巴瘤的遗传易感性]

[Genetic susceptibility of single nucleotide polymorphism in MGMT to non-Hodgkin lymphoma].

作者信息

Yang Fan, Shi Jing-yi, Xu Lan, Ren Li-juan, Zhang Qiao-hua, Zhao Wei-li, Shen Zhi-xiang

机构信息

State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Shanghai Rui Jin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China.

出版信息

Zhonghua Xue Ye Xue Za Zhi. 2009 Sep;30(9):622-5.

PMID:19954624

Abstract

OBJECTIVE

To evaluate the relationship between five single nucleotide polymorphism loci in the MGMT, XPA, XPD and XPG genes and the prevalence of non-Hodgkin's lymphoma.

METHODS

A case-control study of 73 lymphoma cases and 500 healthy controls was conducted and the Mass-ARRAY method was applied for detection of MGMT L84F, MGMT K178R, XPA TSS+62, XPD K751Q and XPG TSS+372.

RESULTS

MGMT L84F (T allele) was associated with an increased risk of non-Hodgkin lymphoma (OR=2.085, 95%CI=1.069-4.068, P=0.029), mainly in B-cell lymphoma, of which the risk increased by 2.403-fold (OR=2.403, 95%CI=1.103-5.235, P=0.024). No statistically significance was found for MGMT K178R, XPA TSS+62, XPD K751Q and XPG TSS+372.

CONCLUSION

Single nucleotide polymorphism in the MGMT gene may closely related to the occurrence of non-Hodgkin lymphoma, especially of B-cell subtype.

摘要

目的

评估O6-甲基鸟嘌呤-DNA甲基转移酶（MGMT）、XPA、XPD和XPG基因中的五个单核苷酸多态性位点与非霍奇金淋巴瘤患病率之间的关系。

方法

对73例淋巴瘤患者和500例健康对照进行病例对照研究，并采用Mass-ARRAY方法检测MGMT L84F、MGMT K178R、XPA TSS+62、XPD K751Q和XPG TSS+372。

结果

MGMT L84F（T等位基因）与非霍奇金淋巴瘤风险增加相关（比值比[OR]=2.085，95%可信区间[CI]=1.069-4.068，P=0.029），主要见于B细胞淋巴瘤，其风险增加2.403倍（OR=2.403，95%CI=1.103-5.235，P=0.024）。MGMT K178R、XPA TSS+62、XPD K751Q和XPG TSS+372未发现统计学意义。