School of Psychological Science, La Trobe University, Bundoora, VIC 3086, Australia.
Behav Brain Res. 2010 Mar 17;208(1):202-8. doi: 10.1016/j.bbr.2009.11.033. Epub 2009 Nov 30.
Developmental programming of neuroendocrine systems is profoundly influenced by environmental cues such as caloric availability. The focus of investigations in this area has been on the effects of under- and malnutrition while there is a paucity of research examining the effects of more mild levels of calorie restriction (CR). Rat dams and their offspring were subjected to one of five dietary regimens: control, CR50% for 3 days preconception, CR25% during gestation, CR25% during lactation, and CR25% during gestation, lactation, and post-weaning (lifelong). Adult male offspring were decapitated and trunk blood collected to assay for basal concentrations of serum adrenocorticotropic hormone (ACTH) and corticosterone (CORT), as well as plasma concentrations of adrenalin (A) and noradrenalin (NA). Basal serum ACTH was reduced by 35-43% in all dietary regimens except the lifelong group. Although a similar trend was observed in the concentrations of serum CORT, only the decrease in the lactation group attained statistical significance. A was reduced by 33-49% as a result of all dietary regimens and NA was reduced in the gestation and lifelong groups by 51% and 39%, respectively. The potential mechanisms underlying these neuroendocrine alterations are discussed.
神经内分泌系统的发育编程受到环境线索的深刻影响，例如热量供应。该领域研究的重点一直是营养不足和营养不良的影响，而对于更轻度的热量限制（CR）的影响研究则很少。研究人员使母鼠及其后代分别接受以下五种饮食方案之一：对照组、受孕前 3 天 50%CR、妊娠期 25%CR、哺乳期 25%CR 以及妊娠期、哺乳期和断奶后（终生）25%CR。雄性成年后代被断头，采集其 trunk blood 以测定基础血清促肾上腺皮质激素（ACTH）和皮质酮（CORT）浓度，以及血浆肾上腺素（A）和去甲肾上腺素（NA）浓度。除了终生组之外，所有饮食方案都使基础血清 ACTH 降低了 35-43%。尽管血清 CORT 浓度也观察到了类似的趋势，但只有哺乳期组的降低具有统计学意义。所有饮食方案都使 A 降低了 33-49%，而妊娠期和终生组的 NA 分别降低了 51%和 39%。讨论了这些神经内分泌改变的潜在机制。
