Boccardo F, Torrisi R, Zanardi S, Valenti G, Pensa F, De Franchis V, Barreca A, Ferraro P, Minuto F
Istituto Nazionale per la Ricerca sul Cancro, Università di Genova, Italy.
Int J Cancer. 1991 Feb 20;47(4):523-6. doi: 10.1002/ijc.2910470409.
The relationship between intracystic levels of epidermal growth factor (EGF) and those of dehydroepiandrosterone sulphate (DHEA-S), delta-4-androstenedione (delta-4-A), 17-beta-estradiol (17-beta-E) and progesterone (PROG) have been studied in 77 breast cyst fluid (BCF) samples. EGF and all tested hormones appeared to be inversely correlated with the intracystic Na+/K+ ratio (p less than 0.001). Consequently, when the BCFs were subdivided according to the Na+/K+ ratio, significantly higher levels of EGF, DHEA-S, delta-4-A, 17-beta-E and PROG were found in Na+/K+ less than 3 BCFs compared with Na+/K+ greater than 3 BCFs (p less than 0.001 in all cases). Strong direct relationships were found among all steroid hormones when they were correlated to one another (p less than 0.001). Intracystic EGF concentration was directly and significantly correlated with each tested hormone (p less than 0.001). However, the relationship between EGF and steroid hormones appeared to be different in the 2 BCF types (Na+/K+ less than 3 or greater than 3).
在77份乳腺囊肿液（BCF）样本中研究了囊内表皮生长因子（EGF）水平与硫酸脱氢表雄酮（DHEA-S）、δ-4-雄烯二酮（δ-4-A）、17-β-雌二醇（17-β-E）和孕酮（PROG）水平之间的关系。EGF和所有检测的激素似乎都与囊内Na+/K+比值呈负相关（p<0.001）。因此，当根据Na+/K+比值对BCF进行细分时，与Na+/K+大于3的BCF相比，在Na+/K+小于3的BCF中发现EGF、DHEA-S、δ-4-A、17-β-E和PROG的水平显著更高（所有情况均p<0.001）。当所有甾体激素相互关联时，发现它们之间存在很强的直接关系（p<0.001）。囊内EGF浓度与每种检测的激素直接且显著相关（p<0.001）。然而，在两种类型的BCF（Na+/K+小于3或大于3）中，EGF与甾体激素之间的关系似乎有所不同。
