Lai L C, Ghilchik M W, Shaikh N A, Reed M J, James V H
Department of Chemical Pathology, St Mary's Hospital Medical School, London, UK.
Br J Cancer. 1989 Sep;60(3):320-3. doi: 10.1038/bjc.1989.278.
Gross cystic breast disease is a common condition. Women with apocrine breast cysts may be at higher risk of breast cancer than women with cysts which are lined by flattened epithelium. Apocrine cysts have been shown to be associated with higher intracystic levels of dehydroepiandrosterone sulphate and intracystic sodium to potassium ratios of less than 3. In this study we measured the concentrations of epidermal growth factor, dehydroepiandrosterone and its sulphate in breast cyst fluid. The concentrations of all three analytes were significantly higher in cysts with intracystic Na+/K+ ratios of less than 3 than in cysts with electrolyte ratios of greater than or equal to 3 (P less than 0.001). The higher levels of EGF in cysts with low intracystic electrolyte ratios may provide an explanation of why women with apocrine cysts may be at greater risk of breast cancer. Positive correlations were obtained between concentrations of EGF and DHAS and between EGF and DHA, compatible with the view that intracystic EGF levels may be androgen-modulated. A positive correlation was also obtained between DHA and DHAS concentrations which supports the view that DHA in cyst fluid may be derived from the metabolism of DHAS in the breast cyst wall.
乳腺大囊性病是一种常见病症。患有大汗腺型乳腺囊肿的女性可能比囊肿内衬扁平上皮的女性患乳腺癌的风险更高。已表明大汗腺囊肿与囊内硫酸脱氢表雄酮水平较高以及囊内钠钾比小于3有关。在本研究中，我们测量了乳腺囊肿液中表皮生长因子、脱氢表雄酮及其硫酸盐的浓度。囊内Na⁺/K⁺比小于3的囊肿中，所有三种分析物的浓度均显著高于电解质比大于或等于3的囊肿（P小于0.001）。囊内电解质比低的囊肿中较高水平的表皮生长因子可能解释了为什么患有大汗腺囊肿的女性患乳腺癌的风险可能更高。表皮生长因子与硫酸脱氢表雄酮浓度之间以及表皮生长因子与脱氢表雄酮之间呈正相关，这与囊内表皮生长因子水平可能受雄激素调节的观点一致。脱氢表雄酮与硫酸脱氢表雄酮浓度之间也呈正相关，这支持了囊肿液中的脱氢表雄酮可能源自乳腺囊肿壁中硫酸脱氢表雄酮代谢的观点。
