Department of Microbiology and Immunology, Arkansas Children's Nutrition Center, University of Arkansas for Medical Sciences, Little Rock, AR 72202, USA.
J Nutr Biochem. 2010 Apr;21(4):255-60. doi: 10.1016/j.jnutbio.2009.09.002. Epub 2009 Dec 1.
Soy-based diets have been reported to protect against the development of atherosclerosis. However, the underlying mechanism(s) for this protection remains unknown. Although atherosclerosis was traditionally considered a disease associated with impaired lipid metabolism, in recent years the inflammatory components of atherosclerosis have been explored. Recent studies have convincingly delineated that uncontrolled chronic inflammation is the principal contributing factor for the initiation and progression of atherosclerosis. Interaction between activated monocytes and vascular endothelial cells is an early event in atherogenesis. The adhesion of leukocytes, including monocytes, to the inflamed-vascular endothelium and their transmigration into intima initiate the inflammatory processes. Following transmigration, monocytes in the intima are transformed to macrophages, which take up oxidized-LDL (oxLDL) to generate lipid-laden macrophages, also known as foam cells. Hence, in this review article the inflammatory processes associated with atherosclerosis and possible anti-inflammatory functions of soy-based diets contributing to the prevention of atherosclerosis are presented.
以大豆为基础的饮食被报道可以预防动脉粥样硬化的发生。然而，这种保护作用的潜在机制尚不清楚。尽管动脉粥样硬化传统上被认为是一种与脂质代谢受损相关的疾病，但近年来，动脉粥样硬化的炎症成分已经被探索。最近的研究令人信服地描绘了不受控制的慢性炎症是动脉粥样硬化发生和进展的主要促成因素。活化的单核细胞与血管内皮细胞之间的相互作用是动脉粥样硬化形成的早期事件。白细胞（包括单核细胞）与炎症血管内皮的黏附和它们向内膜的迁移启动了炎症过程。迁移后，内膜中的单核细胞转化为巨噬细胞，巨噬细胞摄取氧化低密度脂蛋白（oxLDL），产生富含脂质的巨噬细胞，也称为泡沫细胞。因此，在这篇综述文章中，呈现了与动脉粥样硬化相关的炎症过程以及大豆为基础的饮食可能具有的抗炎功能，有助于预防动脉粥样硬化。
