锂对大鼠的电生理效应。
The electrophysiological effects of lithium in the rat.
作者信息
Samples J R, Seybold M E
出版信息
Int Pharmacopsychiatry. 1977;12(3):160-5. doi: 10.1159/000468303.
The effects of lithium on the tail nerve conduction velocity of the rat were studied. No effect of lithium on the conduction velocity was found, even at toxic serum lithium levels. No effect of lithium on repetitive stimulation of the distal forelimb flexor muscles was seen. The results suggest that electrophysiological measurements do not provide an effective means of titrating serum lithium levels in the rat. The results may have clinical signficance since they provide evidence against neuropathic or neuromuscular transmission defects as the cause of the transient weakness of some patients taking lithium.
研究了锂对大鼠尾神经传导速度的影响。即使在血清锂水平达到中毒程度时，也未发现锂对传导速度有影响。也未观察到锂对前肢远端屈肌重复刺激有影响。结果表明，电生理测量并非滴定大鼠血清锂水平的有效方法。这些结果可能具有临床意义，因为它们提供了证据，反驳了某些服用锂的患者出现短暂肌无力是由神经病变或神经肌肉传递缺陷所致的观点。
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