Section of Chronic Disease Epidemiology, Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520-8034, USA. judith.lichtman @ yale.edu
Cerebrovasc Dis. 2010 Jan;29(2):154-61. doi: 10.1159/000262312. Epub 2009 Dec 1.
Relatively little is known about trends in the utilization or outcomes of carotid endarterectomy (CEA) in the very elderly. We determined trends in the rates of CEA and perioperative (in-hospital and 30-day) and long-term (1-, 2-, 3-, 4- and 5-year) mortality in a US national sample of patients >or=80 years of age.
All fee-for-service Medicare patients (80-89 and >or=90 years of age) who had a CEA [ICD-9-CM (International Classification of Diseases, Ninth Revision, Clinical Modification): 38.12] from 1993 to 1999 were identified using the Centers for Medicare and Medicaid Services Inpatient Standard Analytic Files. Demographic characteristics and comorbid conditions were determined using ICD-9-CM diagnostic codes within the year prior to the index hospitalization for CEA.
A total of 140,376 CEA were performed in patients aged 80-89 years and 6,446 in those aged >or=90 years during this 7-year period. The annual number of operations increased from 13,115 in 1993 to 21,582 in 1999 for octogenarians, and from 481 in 1993 to 1,257 in 1999 for nonagenarians. Perioperative mortality was 2.2% in octogenarians and 3.3% in nonagenarians. Long-term mortality increased by approximately 10% per year after the operation, and was 43% in octogenarians and 56% in nonagenarians at 5 years. Perioperative mortality rates remained relatively stable over the 7-year period for both age groups although comorbidities increased.
The number of CEA performed in the very elderly in the USA increased from 1993 to 1999. Perioperative mortality rates were high compared with trial results, while long-term survivorship was comparable to that of similarly-aged peers in the USA.
关于高龄患者颈动脉内膜切除术(CEA)使用率或结果的趋势,人们知之甚少。我们在美国全国范围内 80 岁以上患者样本中确定了 CEA 及围手术期(住院内和 30 天)和长期(1 年、2 年、3 年、4 年和 5 年)死亡率的趋势。
使用医疗保险和医疗补助服务中心(Centers for Medicare and Medicaid Services)住院标准分析文件,确定 1993 年至 1999 年期间年龄在 80-89 岁和 80 岁以上的所有 CEA(ICD-9-CM [国际疾病分类,第九版,临床修订版]:38.12)患者。围手术期死亡率在 80-89 岁的患者中为 2.2%,在 90 岁以上的患者中为 3.3%。长期死亡率在手术后每年增加约 10%,80 岁组为 43%,90 岁组为 56%。在 7 年期间,80-89 岁患者的手术数量从 1993 年的 13115 例增加到 1999 年的 21582 例,90 岁以上患者的手术数量从 1993 年的 481 例增加到 1999 年的 1257 例。尽管合并症有所增加,但两组围手术期死亡率在 7 年期间相对稳定。
1993 年至 1999 年,美国进行 CEA 的非常高龄患者数量有所增加。与试验结果相比,围手术期死亡率较高,而长期生存率与美国同年龄组相似。