Instituto de Investigaciones Cardiológicas Prof. Dr Alberto C. Taquini, Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires, Argentina.
J Cardiovasc Med (Hagerstown). 2010 Apr;11(4):260-4. doi: 10.2459/JCM.0b013e3283356607.
In 1939, two independent teams, in Buenos Aires and Indianapolis, identified the polypeptide angiotensin. In 1934, Goldblatt et al. demonstrated that partial occlusion of the renal arteries produces hypertension in dogs, and Houssay in 1936 predicted the presence of a humoral mechanism and, with Fasciolo, demonstrated that the ischemic kidneys released a pressor substance that increased the recipient's blood pressure. Later on, Taquini proved that the rise in blood pressure that follows the re-establishment of circulation in kidneys was also produced by a plasmatic substance from the venous blood of acute ischemic kidneys and it was called 'hypertensin'. Then, they proved that it was the result of an enzymatic reaction in which renin was the enzyme and plasma the substrate. At the same time, in 1939, Page et al. postulated that renin activated by plasma becomes vasoactive and the substance was called 'angiotonin'. Page's group began in 1937, with the purification of renin, studying its renal hemodynamic effects. Later on, Page et al. acknowledged in 1943 the enzymatic nature of the system and renamed their so-called renin-activator as renin substrate. Both groups fused the two original names into 'angiotensin' during a meeting at Michigan in 1958, making the 'adventure of the discovery of angiotensin' a reality.
1939 年，两个独立的团队，分别位于布宜诺斯艾利斯和印第安纳波利斯，鉴定出了多肽血管紧张素。1934 年，Goldblatt 等人证明部分肾动脉阻塞会导致狗的高血压，而 Houssay 在 1936 年预测存在体液机制，并与 Fasciolo 一起证明缺血肾脏释放出一种加压物质，可增加受者的血压。后来，Taquini 证明，在肾脏循环重新建立后血压升高也是由急性缺血肾脏静脉血中的血浆物质引起的，该物质被称为“高血压素”。然后，他们证明这是一种酶反应的结果，其中肾素是酶，血浆是底物。与此同时，1939 年，Page 等人假设由血浆激活的肾素变得具有血管活性，该物质被称为“血管紧张素”。Page 小组于 1937 年开始纯化肾素，研究其对肾脏血流动力学的影响。后来，Page 等人在 1943 年承认该系统的酶性质，并将他们所谓的肾素激活剂重新命名为肾素底物。1958 年在密歇根州的一次会议上，两个小组将这两个最初的名字融合在一起，形成了“血管紧张素”，使“发现血管紧张素的冒险”成为现实。
