Basso N, Terragno N A
Instituto de Investigaciones Cardiológicas, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina.
Hypertension. 2001 Dec 1;38(6):1246-9. doi: 10.1161/hy1201.101214.
The history of the discovery of the renin-angiotensin system began in 1898 with the studies made by Tigerstedt and Bergman, who reported the pressor effect of renal extracts; they named the renal substance renin based on its origin. In 1934, Harry Goldblatt induced experimental hypertension in dogs by clamping a renal artery. About 1936, simultaneously in the Medical School of the University of Buenos Aires, Argentina, and in the Eli-Lilly Laboratories in Indianapolis, 2 independent groups of researchers, using the Goldblatt technique to produce experimental hypertension, demonstrated renal secretion of a pressor agent similar to renin. In the following years, both teams described the presence of a new compound in the renal vein blood of ischemic kidneys. This agent was extracted from blood with 70% acetone and had a short pressor effect. The final conclusion was that renin acted enzymatically on a plasma protein to produce the new substance. In Buenos Aires, it was called hypertensin; in the United States, angiotonin. In 1958, Eduardo Braun Menéndez from Argentina and Irving H. Page from the United States agreed to name it angiotensin.
肾素-血管紧张素系统的发现历程始于1898年，当时蒂格斯特德和伯格曼进行了相关研究，他们报告了肾提取物的升压作用；基于其来源，他们将这种肾脏物质命名为肾素。1934年，哈里·戈德布拉特通过钳夹肾动脉在狗身上诱发了实验性高血压。大约在1936年，阿根廷布宜诺斯艾利斯大学医学院和印第安纳波利斯的礼来实验室同时有两组独立的研究人员，使用戈德布拉特技术制造实验性高血压，证明肾脏分泌一种类似于肾素的升压剂。在随后的几年里，两个团队都描述了缺血性肾脏肾静脉血中存在一种新化合物。这种物质用70%的丙酮从血液中提取出来，具有短暂的升压作用。最终结论是肾素对血浆蛋白起酶促作用以产生这种新物质。在布宜诺斯艾利斯，它被称为高血压素；在美国，被称为血管紧张素。1958年，来自阿根廷的爱德华多·布劳恩·梅嫩德斯和来自美国的欧文·H·佩奇同意将其命名为血管紧张素。
