Cherne Pablo Nicolás, Young Pablo
Rev Med Chil. 2014 Sep;142(9):1210-6. doi: 10.4067/S0034-98872014000900017.
The discovery of the renin-angiotensin-aldosterone system (RAS) was one of the important findings in physiology. Two research groups, in both North and South America, independently discovered that renin released a novel vasopressor agent. The Argentine group named it hypertensin, and called hypertensinogen to its plasma protein substrate. The group from the United States named it angiotonin. In 1958, Braun Menendez and Irvine Page suggested that the peptide's name should be angiotensin. Development of angiotensin converting enzyme (ACE) inhibitors proved that the RAS is effective in controlling hypertension and heart failure, and in preventing vascular injury in chronic diseases. Both teams, showing that beyond being great investigators they were remarkable persons, shared the merit of the discovery.
肾素-血管紧张素-醛固酮系统（RAS）的发现是生理学领域的重要发现之一。北美和南美的两个研究小组独立发现，肾素可释放一种新型血管加压剂。阿根廷小组将其命名为高血压素，并将其血浆蛋白底物称为高血压素原。美国小组将其命名为血管紧张素。1958年，布劳恩·梅嫩德斯和欧文·佩奇建议将该肽命名为血管紧张素。血管紧张素转换酶（ACE）抑制剂的研发证明，RAS在控制高血压和心力衰竭以及预防慢性疾病中的血管损伤方面是有效的。两个小组都证明了他们不仅是伟大的研究者，更是杰出的人，共同分享了这一发现的功绩。
