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本文引用的文献

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Heme oxygenase-1 protects interstitial cells of Cajal from oxidative stress and reverses diabetic gastroparesis.血红素加氧酶-1可保护 Cajal 间质细胞免受氧化应激，并逆转糖尿病胃轻瘫。
Gastroenterology. 2008 Dec;135(6):2055-64, 2064.e1-2. doi: 10.1053/j.gastro.2008.09.003. Epub 2008 Sep 11.
2
Physicochemical properties, pharmacokinetics, and pharmacodynamics of intravenous hematin: a literature review.静脉注射血晶素的物理化学性质、药代动力学和药效学：文献综述
Adv Ther. 2008 Sep;25(9):842-57. doi: 10.1007/s12325-008-0094-y.
3
Pharmacological and clinical aspects of heme oxygenase.血红素加氧酶的药理学与临床研究进展
Pharmacol Rev. 2008 Mar;60(1):79-127. doi: 10.1124/pr.107.07104. Epub 2008 Mar 6.
4
Pharmacologic induction of heme oxygenase-1.血红素加氧酶-1的药理学诱导
Antioxid Redox Signal. 2007 Dec;9(12):2227-39. doi: 10.1089/ars.2007.1783.
5
Upregulation of heme oxygenase-1 with hemin prevents D-galactosamine and lipopolysaccharide-induced acute hepatic injury in rats.用氯化血红素上调血红素加氧酶-1可预防D-半乳糖胺和脂多糖诱导的大鼠急性肝损伤。
Toxicology. 2007 Jul 31;237(1-3):184-193. doi: 10.1016/j.tox.2007.05.014. Epub 2007 May 21.
6
Physiology and pathophysiology of heme: implications for kidney disease.血红素的生理学与病理生理学：对肾脏疾病的影响
J Am Soc Nephrol. 2007 Feb;18(2):414-20. doi: 10.1681/ASN.2006080894. Epub 2007 Jan 17.
7
Heme oxygenase-1: a novel drug target for atherosclerotic diseases?血红素加氧酶-1：动脉粥样硬化疾病的新型药物靶点？
Circulation. 2006 Nov 14;114(20):2178-89. doi: 10.1161/CIRCULATIONAHA.105.598698.
8
Sustained normalization of high blood pressure in spontaneously hypertensive rats by implanted hemin pump.通过植入血红素泵使自发性高血压大鼠的高血压持续正常化。
Hypertension. 2006 Oct;48(4):685-92. doi: 10.1161/01.HYP.0000239673.80332.2f. Epub 2006 Aug 28.
9
Heme oxygenase-1: a provenance for cytoprotective pathways in the kidney and other tissues.血红素加氧酶-1：肾脏及其他组织中细胞保护途径的来源。
Kidney Int. 2006 Aug;70(3):432-43. doi: 10.1038/sj.ki.5001565. Epub 2006 Jun 14.
10
Heme oxygenase-1/carbon monoxide: from basic science to therapeutic applications.血红素加氧酶-1/一氧化碳：从基础科学到治疗应用
Physiol Rev. 2006 Apr;86(2):583-650. doi: 10.1152/physrev.00011.2005.

首例人体研究证明血红素加氧酶-1在人体内的药理学激活作用。

First-in-human study demonstrating pharmacological activation of heme oxygenase-1 in humans.

机构信息

Enteric Neurosciences Program, Division of Gastroenterology and Hepatology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota, USA.

出版信息

Clin Pharmacol Ther. 2010 Feb;87(2):187-90. doi: 10.1038/clpt.2009.221. Epub 2009 Dec 2.

DOI:10.1038/clpt.2009.221
PMID:19956091
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2906143/
Abstract

Heme oxygenase (HO)-1 degrades heme and protects against oxidative stress, but it has not been pharmacologically induced in humans. In this randomized study of 10 healthy volunteers, hemin (3 mg/kg intravenously in 25% albumin) was shown to increase plasma HO-1 protein concentration four- to fivefold and HO-1 activity ~15-fold relative to baseline at 24 and 48 h (placebo -56.41 +/- 6.31 (baseline), 69.79 +/- 13.00 (24 h), 77.44 +/- 10.62 (48 h) vs. hemin -71.70 +/- 9.20 (baseline), 1,126.20 +/- 293.30 (24 h), 1,192.20 +/- 333.30 (48 h)) in four of five subjects as compared with albumin alone (P </= 0.03). This represents the overcoming of a fundamental hurdle to HO-1 research in humans.

摘要

血红素加氧酶-1（HO-1）可降解血红素并抵抗氧化应激，但尚未在人体中进行药理学诱导。在这项针对 10 名健康志愿者的随机研究中，与单独使用白蛋白相比，静脉内给予 3mg/kg 的血红素（25%白蛋白）可使血浆 HO-1 蛋白浓度在 24 和 48 小时时增加 4-5 倍，HO-1 活性增加 15 倍（安慰剂-56.41 +/- 6.31（基线），69.79 +/- 13.00（24 小时），77.44 +/- 10.62（48 小时）vs. 血红素-71.70 +/- 9.20（基线），1126.20 +/- 293.30（24 小时），1192.20 +/- 333.30（48 小时）），在五名受试者中的四名中（P </= 0.03）。这代表着在人体 HO-1 研究中克服了一个基本障碍。