Graf Thomas, Enver Tariq
Center for Genomic Regulation and ICREA, 08003 Barcelona, Spain.
Nature. 2009 Dec 3;462(7273):587-94. doi: 10.1038/nature08533.
The ability to produce stem cells by induced pluripotency (iPS reprogramming) has rekindled an interest in earlier studies showing that transcription factors can directly convert specialized cells from one lineage to another. Lineage reprogramming has become a powerful tool to study cell fate choice during differentiation, akin to inducing mutations for the discovery of gene functions. The lessons learnt provide a rubric for how cells may be manipulated for therapeutic purposes.
通过诱导多能性产生干细胞的能力（iPS重编程）重新唤起了人们对早期研究的兴趣，这些研究表明转录因子可以直接将一种谱系的特化细胞转化为另一种谱系的细胞。谱系重编程已成为研究分化过程中细胞命运选择的有力工具，类似于为发现基因功能而诱导突变。所学到的经验教训为如何出于治疗目的操纵细胞提供了一个准则。
