诱导多能干细胞生成的精英模型和随机模型。
Elite and stochastic models for induced pluripotent stem cell generation.
作者信息
Yamanaka Shinya
机构信息
Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto 606-8507, Japan.
出版信息
Nature. 2009 Jul 2;460(7251):49-52. doi: 10.1038/nature08180.
PMID:19571877
Abstract
Induced pluripotent stem cells offer unprecedented potential for disease research, drug screening, toxicology and regenerative medicine. However, the process of reprogramming is inefficient and often incomplete. Here I consider reasons for bottlenecks in induced pluripotent stem cell generation, and propose a model in which most or all cells have the potential to become pluripotent.
摘要
诱导多能干细胞为疾病研究、药物筛选、毒理学和再生医学提供了前所未有的潜力。然而，重编程过程效率低下且往往不完全。在此，我探讨了诱导多能干细胞生成过程中瓶颈的原因，并提出了一个模型，其中大多数或所有细胞都有成为多能细胞的潜力。
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