Shiraishi Makoto, Sowa Yoshihiro, Sunaga Ataru, Yamamoto Kenta, Okazaki Mutsumi
Department of Plastic and Reconstructive Surgery, The University of Tokyo Hospital, Tokyo, Japan.
Department of Plastic Surgery, Jichi Medical University, Japan.
Regen Ther. 2024 Dec 15;28:153-160. doi: 10.1016/j.reth.2024.12.006. eCollection 2025 Mar.
The skin is a complex organ that includes various stem cell populations. Current approaches for non-healing skin defects are sometimes inadequate and many attempts have been made to regenerate skin integrity. The aim of this review is to bridge the gap between basic research and clinical application of skin integrity regeneration.
A literature search was carried out in PubMed using combinations of the keywords "skin integrity", "tissue-engineered skin", "bioengineered skin", and "skin regeneration". Articles published from 1968 to 2023 reporting evidence from and skin regeneration experiments were included.
These articles showed that stem cells can be differentiated into normal skin cells, including keratinocytes, and are a significant source of skin organoids, which are useful for investigating skin biology; and that emerging direct reprogramming methods have great potential to regenerate skin from the wounded skin surface.
Recent advances in skin regeneration will facilitate further advancement of both basic and clinical research in skin biology.
皮肤是一个复杂的器官，包含多种干细胞群。目前针对难愈合皮肤缺损的方法有时并不充分，人们已进行了许多尝试来重建皮肤完整性。本综述的目的是弥合皮肤完整性再生的基础研究与临床应用之间的差距。
在PubMed中使用“皮肤完整性”“组织工程皮肤”“生物工程皮肤”和“皮肤再生”等关键词组合进行文献检索。纳入了1968年至2023年发表的报道体内和体外皮肤再生实验证据的文章。
这些文章表明，干细胞可分化为正常皮肤细胞，包括角质形成细胞，是皮肤类器官的重要来源，有助于研究皮肤生物学；新兴的直接重编程方法具有从伤口皮肤表面再生皮肤的巨大潜力。
皮肤再生的最新进展将推动皮肤生物学基础研究和临床研究的进一步发展。
