Tomasi Paolo A, Fanciulli Giuseppe, Casti Tiziana, Delitala Giuseppe
Dipartimento-Struttura Clinica Medica-Patologia Speciale Medica, Università degli Studi di Sassari, Viale San Pietro 8, 07100 Sassari, Italy.
Int J Pediatr Endocrinol. 2009;2009:578610. doi: 10.1155/2009/578610. Epub 2009 Feb 26.
Galactocele is a benign breast lesion, usually occurring in nursing women. This lesion is a rare cause of breast enlargement in children. In this paper we describe the case of an infant with hyperprolactinemia (which persisted throughout 15 years of clinical observation) and bilateral galactocele. We speculate that a congenital midline defect in our patient might have impaired the normal dopaminergic inhibitory tone on pituitary lactotroph cells, thus leading to an increased prolactin secretion by the pituitary gland; this, in turn, might have favored the development of the galactocele.
乳腺囊肿是一种良性乳腺病变，通常发生于哺乳期女性。这种病变是儿童乳腺增大的罕见原因。在本文中，我们描述了一名患有高催乳素血症（在15年的临床观察中一直存在）并伴有双侧乳腺囊肿的婴儿病例。我们推测，我们的患者先天性中线缺陷可能损害了垂体催乳素细胞上正常的多巴胺能抑制作用，从而导致垂体催乳素分泌增加；反过来，这可能有利于乳腺囊肿的发展。
