乳糜泻患者的血清催乳素：疾病活动的标志物
Serum prolactin in coeliac disease: a marker for disease activity.
作者信息
Reifen R, Buskila D, Maislos M, Press J, Lerner A
机构信息
School of Nutritional Sciences, Hebrew University of Jerusalem, Rehovot.
出版信息
Arch Dis Child. 1997 Aug;77(2):155-7. doi: 10.1136/adc.77.2.155.
Prolactin, a polypeptide hormone of anterior pituitary origin, has pronounced physiological effects on growth, reproduction, and osmoregulation. Increasing evidence indicates that prolactin also has an immunomodulatory influence on the immune system. The status of prolactin in patients with coeliac disease was investigated by obtaining serum samples from 48 patients with active and non-active coeliac disease. These were compared with samples from 20 children with familial Mediterranean fever and 65 normal controls. Serum prolactin in patients with active coeliac disease was significantly higher than in the other groups studied and reference values. Serum prolactin correlated well with the degree of mucosal atrophy and with the serum concentration of antiendomysial antibodies. Prolactin may play a part in immune modulation in the intestinal damage of coeliac disease and serve as a potential marker for disease activity.
催乳素是一种源于垂体前叶的多肽激素，对生长、生殖和渗透压调节具有显著的生理作用。越来越多的证据表明，催乳素对免疫系统也具有免疫调节作用。通过采集48例活动期和非活动期乳糜泻患者的血清样本，对乳糜泻患者体内催乳素的状况进行了研究。将这些样本与20例家族性地中海热患儿及65例正常对照者的样本进行了比较。活动期乳糜泻患者的血清催乳素水平显著高于其他研究组及参考值。血清催乳素与黏膜萎缩程度及抗肌内膜抗体的血清浓度密切相关。催乳素可能在乳糜泻肠道损伤的免疫调节中发挥作用，并可作为疾病活动的潜在标志物。
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