通过高分辨率傅里叶域光学相干断层扫描诊断的与他莫昔芬使用相关的微囊样黄斑病变。
Microcystoid maculopathy associated with tamoxifen use diagnosed by high-resolution fourier-domain optical coherence tomography.
作者信息
Park Susanna S, Zawadzki Robert J, Truong Steven N, Choi Stacey S, Werner John S
机构信息
Department of Ophthalmology & Vision Science, University of California at Davis Medical Center, Sacramento, California.
出版信息
Retin Cases Brief Rep. 2009 Winter;3(1):33-5. doi: 10.1097/ICB.0b013e31815e93cf.
PURPOSE
To describe a case of microcystoid maculopathy diagnosed by high-resolution Fourier-domain optical coherence tomography (Fd-OCT) in a patient treated with tamoxifen who had previously unexplained vision loss.
METHODS
Report of a case of a 66-year-old woman treated with tamoxifen for 4 years who had progressive unexplained vision loss in the left eye for 2 years.
RESULTS
Visual acuity was 20/25 in the right eye and 20/70 in the left eye. Findings of funduscopy and fluorescein angiography were unremarkable except for minimal pigment alteration in the macula in the left eye. Stratus OCT showed possible microcystoid changes in the fovea in both eyes. Fd-OCT revealed scattered intraretinal microcystoid changes and patches of focal loss of photoreceptors in the macula in both eyes with foveal involvement in the left eye. Full-field electroretinogram was normal. Multifocal electroretinogram showed some decreased response in the peripheral macula and borderline low foveal response in both eyes.
CONCLUSION
Microcystoid maculopathy associated with tamoxifen use can be diagnosed by Fd-OCT in a normal appearing fundus. It can present as unexplained vision loss.
目的
描述一例在接受他莫昔芬治疗的患者中通过高分辨率傅里叶域光学相干断层扫描（Fd-OCT）诊断出的微囊样黄斑病变，该患者此前存在无法解释的视力丧失。
方法
报告一例66岁女性，接受他莫昔芬治疗4年，左眼渐进性出现无法解释的视力丧失2年。
结果
右眼视力为20/25，左眼视力为20/70。眼底镜检查和荧光素血管造影结果无明显异常，仅左眼黄斑区有轻微色素改变。Stratus OCT显示双眼黄斑中心凹可能存在微囊样改变。Fd-OCT显示双眼黄斑区有散在的视网膜内微囊样改变和局部光感受器缺失区域，左眼黄斑中心凹受累。全视野视网膜电图正常。多焦视网膜电图显示双眼周边黄斑区反应有所下降，黄斑中心凹反应临界偏低。
结论
使用他莫昔芬相关的微囊样黄斑病变可通过Fd-OCT在眼底外观正常的情况下诊断出来。它可表现为无法解释的视力丧失。
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