黄斑脱离视网膜脱离修复术后的高分辨率傅里叶域光学相干断层扫描和微视野检查结果

High-resolution Fourier-domain optical coherence tomography and microperimetric findings after macula-off retinal detachment repair.

作者信息

Smith Allison J, Telander David G, Zawadzki Robert J, Choi Stacey S, Morse Lawrence S, Werner John S, Park Susanna S

机构信息

Department of Ophthalmology and Vision Science, University of California Davis Medical Center, Sacramento, California, USA.

出版信息

Ophthalmology. 2008 Nov;115(11):1923-9. doi: 10.1016/j.ophtha.2008.05.025. Epub 2008 Jul 31.

DOI:10.1016/j.ophtha.2008.05.025

PMID:18672289

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2735404/

Abstract

OBJECTIVE

To evaluate the morphologic changes in the macula of subjects with repaired macula-off retinal detachment (RD) using high-resolution Fourier-domain optical coherence tomography (FD OCT) and to perform functional correlation in a subset of patients using microperimetry (MP-1).

DESIGN

Prospective observational case series.

PARTICIPANTS

Seventeen eyes from 17 subjects who had undergone anatomically successful repair for macula-off, rhegmatogenous RD at least 3 months earlier and without visually significant maculopathy on funduscopy.

METHODS

FD OCT with axial and transverse resolution of 4.5 mum and 10 to 15 mum, respectively, was used to obtain rapid serial B-scans of the macula, which were compared with that from Stratus OCT. The FD OCT B-scans were used to create a 3-dimensional volume, from which en face C-scans were created. Among 11 patients, MP-1 was performed to correlate morphologic changes with visual function.

MAIN OUTCOME MEASURES

Stratus OCT scans, FD OCT scans, and MP-1 data.

RESULTS

Stratus OCT and FD OCT images of the macula were obtained 3 to 30 months (mean 7 months) postoperatively in all eyes. Although Stratus OCT revealed photoreceptor disruption in 2 eyes (12%), FD OCT showed photoreceptor disruption in 13 eyes (76%). This difference was statistically significant (P<0.001, chi(2)). Both imaging modalities revealed persistent subretinal fluid in 2 eyes (12%) and lamellar hole in 1 eye. Among 7 subjects who had reliable MP-1 data, areas of abnormal function corresponded to areas of photoreceptor layer disruptions or persistent subretinal fluid in 5 subjects (71%); one subject had normal FD OCT and MP-1.

CONCLUSIONS

Photoreceptor disruption after macula-off RD repair is a common abnormality in the macula that is detected better with FD OCT than Stratus OCT. A good correlation between MP-1 abnormality and presence of photoreceptor disruption or subretinal fluid on FD OCT demonstrates that these anatomic abnormalities contribute to decreased visual function after successful repair.

摘要

目的

使用高分辨率傅里叶域光学相干断层扫描（FD OCT）评估黄斑脱离视网膜脱离（RD）修复患者黄斑的形态学变化，并对部分患者使用微视野计（MP - 1）进行功能相关性分析。

设计

前瞻性观察病例系列。

参与者

17例患者的17只眼，这些患者至少在3个月前接受了黄斑脱离、孔源性RD的解剖学成功修复，且眼底检查无明显黄斑病变。

方法

分别使用轴向分辨率和横向分辨率为4.5μm和10至15μm的FD OCT获取黄斑的快速连续B扫描，并与Stratus OCT的扫描结果进行比较。FD OCT B扫描用于创建三维容积，从中生成表面增强C扫描。在11例患者中，进行MP - 1以将形态学变化与视觉功能相关联。

主要观察指标

Stratus OCT扫描、FD OCT扫描和MP - 1数据。

结果

所有眼均在术后3至30个月（平均7个月）获得黄斑的Stratus OCT和FD OCT图像。虽然Stratus OCT显示2只眼（12%）存在光感受器破坏，但FD OCT显示13只眼（76%）存在光感受器破坏。这种差异具有统计学意义（P<0.001，卡方检验）。两种成像方式均显示2只眼（12%）存在持续性视网膜下液，1只眼存在板层裂孔。在7例有可靠MP - 1数据的患者中，5例（71%）功能异常区域与光感受器层破坏或持续性视网膜下液区域相对应；1例患者FD OCT和MP - 1结果正常。