免疫细胞功能中磷脂酰肌醇4,5 - 二磷酸（PIP(2)）信号的空间隔离
Spatial Segregation of Phosphatidylinositol 4,5-Bisphosphate (PIP(2)) Signaling in Immune Cell Functions.
作者信息
Johnson Corey M, Rodgers William
机构信息
Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation.
出版信息
Immunol Endocr Metab Agents Med Chem. 2008 Dec 1;8(4):349-357. doi: 10.2174/187152208787169233.
Abstract
Phosphatidylinositol 4,5-bisphosphate (PIP(2)) is a prevalent phosphoinositide in the inner leaflet of the plasma membrane. PIP(2) associates with an ever-growing list of proteins, and participates in a variety of cellular processes. PIP(2) signaling to the actin cytoskeleton transduces specific signals necessary for changes in morphology, motility, endocytosis, exocytosis, phagocytosis, and cell activation. The mechanism(s) by which PIP(2) signaling pathways are specific is a topic of intense investigation. One working model is the compartmentalization of PIP(2)-mediated signaling by concentrating PIP(2) in cholesterol-dependent membrane rafts, therefore providing spatial and temporal regulation. Here we discuss properties of PIP(2) signaling to the actin cytoskeleton in immune cell functioning, the association of PIP(2) cellular pools with membrane rafts, and recent work investigating models for compartmentalization of PIP(2)-mediated signaling in membrane rafts to the actin cytoskeleton.
摘要
磷脂酰肌醇-4,5-二磷酸（PIP₂）是质膜内小叶中一种普遍存在的磷酸肌醇。PIP₂与越来越多的蛋白质相关联，并参与多种细胞过程。PIP₂向肌动蛋白细胞骨架发出信号，转导形态变化、运动、内吞作用、外排作用、吞噬作用和细胞激活所需的特定信号。PIP₂信号通路具有特异性的机制是一个深入研究的课题。一个工作模型是通过将PIP₂集中在胆固醇依赖性膜筏中来对PIP₂介导的信号进行区室化，从而提供空间和时间调节。在这里，我们讨论了PIP₂信号向免疫细胞功能中的肌动蛋白细胞骨架发出信号的特性、PIP₂细胞池与膜筏的关联，以及最近研究膜筏中PIP₂介导的信号向肌动蛋白细胞骨架区室化模型的工作。
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