Qi Wen-Ting, Sun Jian-Dong, Xu Ai-Qiang, Zhang Li, Li Ren-Peng, Ma Ji-Xiang, Guo Xiao-Lei, Fan Qing-Ying, Yang He
School of Public Health, Shandong University, Jinan, China.
Zhonghua Liu Xing Bing Xue Za Zhi. 2009 Jul;30(7):679-83.
To comprehensively measure the burden of hepatitis B, liver cirrhosis and liver cancer in Shandong province, using disability-adjusted life years (DALYs) to estimate the disease burden attribute to hepatitis B virus (HBV) infection.
Based on the mortality data of hepatitis B, liver cirrhosis and liver cancer derived from the third National Sampling Retrospective Survey for Causes of Death during 2004 and 2005, the incidence data of hepatitis B and the prevalence and the disability weights of liver cancer gained from the Shandong Cancer Prevalence Sampling Survey in 2007, we calculated the years of life lost (YLLs), years lived with disability (YLDs) and DALYs of three diseases following the procedures developed for the global burden of disease (GBD) study to ensure the comparability.
The total burden for hepatitis B, liver cirrhosis and liver cancer were 211,616 (39,377 YLLs and 172,239 YLDs), 16,783 (13,497 YLLs and 3286 YLDs) and 247,795 (240,236 YLLs and 7559 YLDs) DALYs in 2005 respectively, and men were 2.19, 2.36 and 3.16 times as that for women, respectively in Shandong province. The burden for hepatitis B was mainly because of disability (81.39%). However, most burden on liver cirrhosis and liver cancer were due to premature death (80.42% and 96.95%). The burden of each patient related to hepatitis B, liver cirrhosis and liver cancer were 4.8, 13.73 and 11.11 respectively.
Hepatitis B, liver cirrhosis and liver cancer caused considerable burden to the people living in Shandong province, indicating that the control of hepatitis B virus infection would bring huge potential benefits.
综合衡量山东省乙型肝炎、肝硬化和肝癌的疾病负担，采用伤残调整生命年（DALYs）评估乙肝病毒（HBV）感染所致的疾病负担。
基于2004年至2005年第三次全国死因抽样回顾调查得出的乙型肝炎、肝硬化和肝癌死亡率数据，以及2007年山东省癌症患病率抽样调查获得的乙型肝炎发病率数据、肝癌患病率和伤残权重，按照全球疾病负担（GBD）研究制定的程序计算三种疾病的生命损失年数（YLLs）、伤残生存年数（YLDs）和DALYs，以确保可比性。
2005年，山东省乙型肝炎、肝硬化和肝癌的总疾病负担分别为211,616（39,377 YLLs和172,239 YLDs）、16,783（13,497 YLLs和3286 YLDs）和247,795（240,236 YLLs和7559 YLDs）DALYs，男性负担分别是女性的2.19倍、2.36倍和3.16倍。乙型肝炎的疾病负担主要源于伤残（81.39%）。然而，肝硬化和肝癌的大部分疾病负担是由于过早死亡（分别为80.42%和96.95%）。与乙型肝炎、肝硬化和肝癌相关的每位患者的疾病负担分别为4.8、13.73和11.11。
乙型肝炎、肝硬化和肝癌给山东省居民造成了相当大的疾病负担，表明控制乙肝病毒感染将带来巨大潜在益处。
