Digestive Department, Beijing Chao-Yang Hospital, Capital Medical University, Chao Yang District, Beijing 100020, China.
Gastroenterol Res Pract. 2012;2012:516140. doi: 10.1155/2012/516140. Epub 2012 Jun 3.
Aim. To investigate the factors contributing to health-related quality of life (HRQOL) in Chinese patients with chronic liver disease (CLD). Methods. HRQOL was measured with SF-36v2 Chinese version. Demographic and clinical data were collected, and patients with liver cirrhosis were divided into Child's Class A, B, and C according to Child-Turcotte-Pugh scoring system. Results. A total of 392 Chinese patients with CLD and 91 healthy controls were enrolled. HRQOL in patients with CLD was lower than that in healthy controls. Score of PCS in healthy controls was 54.6 ± 5.5 and in CLD was 47.8 ± 8.8 (P = 0.000). Score of MCS in healthy controls was 56.4 ± 8.1 and in CLD was 51.7 ± 7.4 (P = 0.000). Increasing severity of CLD from no cirrhosis to advanced cirrhosis was associated with a decrease on all domains of the SF-36 (P < 0.05). Stepwise linear regression analysis showed that severity of disease, age, present ascites, present varices, and prothrombin time had significant effect on physical health area. Severity of disease, female, present varices, total bilirubin, prothrombin time, and hemoglobin had significant effect on mental health area. Conclusions. Patients with CLD had impaired HRQOL. Increasing severity of CLD was associated with a decrease on HRQOL. Old age, female gender, advanced stage of CLD, present ascites, hyperbilirubinemia, and prolonging prothrombin time were important factors reducing HRQOL.
目的。调查导致中国慢性肝病 (CLD) 患者健康相关生活质量 (HRQOL) 的因素。方法。使用 SF-36v2 中文版测量 HRQOL。收集人口统计学和临床数据，并根据 Child-Turcotte-Pugh 评分系统将肝硬化患者分为 A、B 和 C 级。结果。共纳入 392 名中国 CLD 患者和 91 名健康对照者。CLD 患者的 HRQOL 低于健康对照者。健康对照组的 PCS 评分为 54.6±5.5，CLD 组为 47.8±8.8（P=0.000）。健康对照组的 MCS 评分为 56.4±8.1，CLD 组为 51.7±7.4（P=0.000）。从无肝硬化到进展性肝硬化的 CLD 严重程度增加与 SF-36 的所有领域得分降低相关（P<0.05）。逐步线性回归分析显示，疾病严重程度、年龄、腹水、静脉曲张和凝血酶原时间对身体健康领域有显著影响。疾病严重程度、女性、静脉曲张、总胆红素、凝血酶原时间和血红蛋白对心理健康领域有显著影响。结论。CLD 患者的 HRQOL 受损。CLD 严重程度的增加与 HRQOL 的下降相关。年龄较大、女性、CLD 晚期、腹水、高胆红素血症和凝血酶原时间延长是降低 HRQOL 的重要因素。
