Ding Ding, Hong Zhen, Wang Wen-zhi, Wu Jian-zhong, de Boer Hanneke M, Prilipko Leonid, Sander Josemir W
Department of Biostatistics and Epidemiology, Institute of Neurology, Fudan University, WHO Collaborating Center for Research and Training in Neurosciences, Shanghai, China.
Epilepsia. 2006 Dec;47(12):2032-7. doi: 10.1111/j.1528-1167.2006.00802.x.
To demonstrate the application of Disability Adjusted Life Year (DALY) as an aid in health outcome measures to evaluate the epilepsy disease burden in rural China and to provide Chinese data to achieve a better understanding of disease burden due to epilepsy.
The DALY is the sum of the number of years of survival with disability (Years Lived with Disability, YLD) and the number of years lost because of premature mortality (Years of Life Lost, YLL). We calculated the YLD based on the prevalence survey of epilepsy among 66,393 people sampled in Heilongjiang, Henan, Jiangsu, Ningxia, Shanghai, and Shanxi provinces in 2000. The epilepsy mortality data from Chinese literature provided the YLL due to epilepsy. We applied sensitivity analysis to evaluate the influence of uncertainty on the epilepsy mortality value and disability weight in the study.
In 2000, epilepsy caused 1.83 and 2.48 DALY lost per 1,000 population in Henan and Ningxia province, which had the lowest and the highest DALY lost among the six study areas. Overall, epilepsy caused 1.41 YLLs and 0.67 YLDs per 1,000 population; thus the DALYs lost because of epilepsy was 2.08 per 1,000 population, representing the epilepsy disease burden in rural China.
The DALY measure, which includes the extent of disability from epilepsy, provides a useful tool for the epilepsy disease burden assessment. The disease burden of epilepsy in China is considered higher than previous estimations.
展示伤残调整生命年（DALY）在健康结果测量中的应用，以评估中国农村地区癫痫疾病负担，并提供中国数据，以便更好地了解癫痫所致疾病负担。
DALY是残疾生存年数（YLD）与过早死亡所致生命年损失数（YLL）之和。我们基于2000年在黑龙江、河南、江苏、宁夏、上海和山西6省66393人样本中的癫痫患病率调查计算YLD。中国文献中的癫痫死亡率数据提供了癫痫所致YLL。我们应用敏感性分析来评估研究中癫痫死亡率值和残疾权重不确定性的影响。
2000年，癫痫在河南省和宁夏回族自治区分别导致每千人口1.83和2.48个伤残调整生命年损失，这两个地区在六个研究地区中伤残调整生命年损失最低和最高。总体而言，癫痫导致每千人口1.41个生命年损失和0.67个残疾生存年数；因此，癫痫所致伤残调整生命年损失为每千人口2.08个，代表了中国农村地区的癫痫疾病负担。
DALY测量方法，包括癫痫所致残疾程度，为癫痫疾病负担评估提供了一个有用工具。中国癫痫的疾病负担被认为高于先前估计。
