（+/-）-grandisol 的高效合成，其特征在于 1,5-烯炔复分解。
An efficient synthesis of (+/-)-grandisol featuring 1,5-enyne metathesis.
机构信息
Department of Chemistry, Furman University, 3300 Poinsett Highway, Greenville, South Carolina 29613, USA.
出版信息
J Org Chem. 2010 Jan 1;75(1):226-8. doi: 10.1021/jo9020375.
Abstract
An eight-step synthesis of (+/-)-grandisol features a key sequence involving a high-yielding, microwave-assisted enyne metathesis to yield a 1-alkenylcyclobutene that is semihydrogenated to yield a silyl-protected grandisol. Metathesis catalyst screens revealed an intriguing trend whereby substrate conversion correlated strongly with the identity of the ligands on the catalyst. In addition, new reactivity of 1-alkenylcyclobutenes toward hydrogenation is described.
摘要
（+/-）-grandisol 的八步合成法的关键步骤涉及到高产率的微波辅助烯炔复分解反应，生成 1-烯基环丁烯，然后将其部分氢化生成硅保护基的 grandisol。复分解催化剂筛选揭示了一个有趣的趋势，即底物转化率与催化剂上配体的特性密切相关。此外，还描述了 1-烯基环丁烯对氢化反应的新反应性。
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