College of Pharmacy, Seoul National University, Seoul 151-742, Korea.
Arch Pharm Res. 2011 Sep;34(9):1437-42. doi: 10.1007/s12272-011-0904-7. Epub 2011 Oct 6.
A versatile and efficient synthetic procedure for the grandisol pheromone library has been established. The key feature of our synthesis involves a versatile and highly regioselective Pd(0)-catalyzed intramolecular allylic alkylation for the key cyclobutane skeleton of grandisol. In this connection, the concise synthesis of (±)-grandisol as well as mechanism study of Pd(0)-catalyzed regioselective cyclization as a key reaction have also been accomplished.
已经建立了一种用于大根香叶醇信息素文库的通用且高效的合成方法。我们的合成关键在于使用多功能且高区域选择性的 Pd(0)催化的分子内烯丙基烷基化反应来构建大根香叶醇的关键环丁烷骨架。在这方面，我们还完成了（±）-大根香叶醇的简洁合成以及作为关键反应的 Pd(0)催化区域选择性环化的机理研究。
