Farmacognosia, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Rosario, Argentina.
J Org Chem. 2010 Jan 1;75(1):211-4. doi: 10.1021/jo902296h.
The presence of a supramolecular network of interactions between library members can lead to very different responses when libraries with identical molecular composition are exposed to the same template. Numerical simulations demonstrate that supramolecular interactions between library members of covalent dynamic combinatorial libraries (DCLs) can affect both degree and selectivity of the response of the library when a template molecule is added.
当具有相同分子组成的文库暴露于相同模板时，文库成员之间存在超分子相互作用网络会导致非常不同的响应。数值模拟表明，当添加模板分子时，共价动态组合文库 (DCL) 中文库成员之间的超分子相互作用会影响文库响应的程度和选择性。
