对含氟立体手性碳中心的环丙烷的对映选择性合成：手性 α-氟碳负离子策略。
Enantioselective synthesis of cyclopropanes that contain fluorinated tertiary stereogenic carbon centers: a chiral α-fluoro carbanion strategy.
机构信息
Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, China.
出版信息
Angew Chem Int Ed Engl. 2012 Jul 9;51(28):6966-70. doi: 10.1002/anie.201202451. Epub 2012 Jun 11.
PMID:22689532
Abstract
Chiral transfer: the fluorinated sulfoximine (see scheme; Ts=p-toluenesulfonyl) was synthesized and used as the first chiral fluoromethylenation reagent for the synthesis of cyclopropanes that contain fluorinated tertiary stereogenic carbon centers in good yields, good diastereoselectivity, and excellent enantioselectivity.
摘要
手性转移
合成了氟化亚砜亚胺（见方案；Ts=p-甲苯磺酰基），并将其用作第一个手性氟亚甲基化试剂，用于合成含有氟化三级立体手性碳原子的环丙烷，产率高、非对映选择性好、对映选择性优异。
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