Stokes R F, Rossman M D
Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia.
J Occup Med. 1991 Jan;33(1):23-8. doi: 10.1097/00043764-199101000-00009.
As testing for beryllium-induced proliferation of bronchoalveolar lavage cells is not suitable for screening, we evaluated the proliferative response of blood cells to beryllium. Twenty-seven patients with chronic beryllium disease, documented by histology and a positive lung proliferative response to beryllium, were compared to 30 controls. A significant difference (p less than .05) was observed between beryllium disease patients and controls with 100 or 10 microM beryllium salts. To evaluate the optimum test parameters and stimulation index cutoff, receiver operating characteristic curves (true positive v false positive) were generated. Maximum predictive value positive (26%) was observed at a stimulation index cutoff of 2.5 which corresponds to a 38% sensitivity and 97% specificity. This suggests that the blood cell proliferation response to beryllium has a limited role in screening for chronic beryllium disease.
由于检测铍诱导的支气管肺泡灌洗细胞增殖不适用于筛查，我们评估了血细胞对铍的增殖反应。将27例经组织学证实且对铍有阳性肺增殖反应的慢性铍病患者与30名对照进行比较。在铍病患者与使用100或10微摩尔铍盐的对照之间观察到显著差异（p小于0.05）。为了评估最佳检测参数和刺激指数临界值，绘制了受试者操作特征曲线（真阳性对假阳性）。在刺激指数临界值为2.5时观察到最大预测阳性值（26%），这对应于38%的灵敏度和97%的特异性。这表明血细胞对铍的增殖反应在慢性铍病筛查中的作用有限。
