Panic and Respiration Laboratory, Institute of Psychiatry, Federal University of Rio de Janeiro, INCT Translational Medicine (CNPq), Rio de Janeiro, RJ, Brazil.
World J Biol Psychiatry. 2010 Mar;11(2 Pt 2):357-63. doi: 10.3109/15622970903144012.
The objective of the study was to investigate and compare the brain cortical activity, as indexed by quantitative electroencephalographic (qEEG) power, coherence and asymmetry measures, in panic disorder (PD) patients during an induced panic attack with a 35% CO(2) challenge test and also in a resting condition. Fifteen subjects with PD were randomly assigned to both 35% CO(2) mixture and atmospheric compressed air, in a double-blind study design, with EEG being recorded for a 20-min period. During induced panic attacks we found a reduced right-sided frontal orbital asymmetry in the beta band, a decreased occipital frontal intra-hemispheric coherence in the delta band at both right and left sides, a left-sided occipital delta inter-hemispheric asymmetry and an increased relative power in the beta wave at T4. Our data showed a disturbed frontal cortical processing, pointing to an imbalance of the frontal and occipital sites, common to both hemispheres, and an increased right posterior activity related to the high arousing panic attack condition. Those findings corroborate the Neuroanatomical hypothesis of PD.
这项研究的目的是调查和比较惊恐障碍（PD）患者在诱发惊恐发作时（通过 35%二氧化碳挑战测试）和静息状态下的大脑皮质活动，其指标为定量脑电图（qEEG）功率、相干性和不对称性测量。15 名 PD 患者被随机分配到 35%二氧化碳混合物和大气压缩空气中，采用双盲研究设计，记录脑电图 20 分钟。在诱发的惊恐发作中，我们发现β频段右侧额眶部的不对称性降低，右、左两侧的δ频段枕额内半球相干性降低，左枕部δ频段的半球间不对称性增加，T4 的β波相对功率增加。我们的数据显示，额叶皮质处理过程受到干扰，表明两个半球的额叶和枕叶部位失衡，与高唤醒惊恐发作状态相关的右后叶活动增加。这些发现证实了 PD 的神经解剖假说。
