Department of Otolaryngology, Baskent University, Faculty of Medicine, Ankara, Turkey.
Am J Rhinol Allergy. 2009 Nov-Dec;23(6):568-70. doi: 10.2500/ajra.2009.23.3371.
Expression of matrix metalloproteinase (MMP)-9 increases in nasal polyp tissues. However, the impact of MMP-9 genotypes on the development of nasal polyposis (NP) is unknown. The aim of this study was to examine a potential association of MMP-9 promoter gene polymorphism with the development of NP.
A prospective and case-control study was performed on 93 patients with NP and 115 controls without sinonasal disease. Genotypes of MMP-9 (-1562C>T) were identified by restriction fragment length polymorphism analyses after polymerase chain reaction.
The frequency of -1562CT genotype of MMP-9 was significantly high in NP patients with aspirin-induced asthma (p = 0.014). Distribution of T allele was significantly high in NP patients with aspirin-induced asthma (p = 0.013). MMP-9 genotypes were not associated with gender or the presence of atopy.
In this study, MMP-9 -1562CT genotype was associated with susceptibility to NP in aspirin-induced asthmatic patients. Because this report is a population-based study, further research should be performed on larger study subjects to reveal the precise role of MMP-9 promoter gene polymorphism in the development of NP.
基质金属蛋白酶（MMP）-9 的表达在鼻息肉组织中增加。然而，MMP-9 基因型对鼻息肉病（NP）的发展的影响尚不清楚。本研究旨在研究 MMP-9 启动子基因多态性与 NP 发展之间的潜在关联。
对 93 例 NP 患者和 115 例无鼻-鼻窦疾病的对照进行前瞻性病例对照研究。通过聚合酶链反应后限制性片段长度多态性分析鉴定 MMP-9（-1562C>T）的基因型。
阿司匹林诱导性哮喘的 NP 患者 MMP-9-1562CT 基因型的频率明显较高（p = 0.014）。阿司匹林诱导性哮喘的 NP 患者 T 等位基因的分布明显较高（p = 0.013）。MMP-9 基因型与性别或特应性无关。
在这项研究中，MMP-9-1562CT 基因型与阿司匹林诱导性哮喘患者 NP 的易感性相关。由于这是一项基于人群的研究，应该在更大的研究对象中进行进一步的研究，以揭示 MMP-9 启动子基因多态性在 NP 发展中的精确作用。
