MMP2 启动子基因型与台湾地区哮喘易感性的显著相关性。
Significant Association of MMP2 Promoter Genotypes to Asthma Susceptibility in Taiwan.
机构信息
Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.
Division of Chest Medicine, Department of Internal Medicine, Taichung Tzu Chi Hospital, Taichung, Taiwan, R.O.C.
出版信息
In Vivo. 2020 Nov-Dec;34(6):3181-3186. doi: 10.21873/invivo.12153.
BACKGROUND/AIM: Matrix metalloproteinase 2 (MMP2) is reported to be overexpressed in asthma; however, its genotypic contribution to asthma is not well studied. Therefore, we examined the association of MMP2 genotypes with asthma risk among Taiwanese.
MATERIALS AND METHODS
One hundred and ninety-eight asthma patients and 453 non-asthmatic subjects were determined with respect to their MMP2 -1306 (rs243845) and -735 (rs2285053) genotypes.
RESULTS
CT and TT at MMP2 rs243845 are 17.7% and 1.5% among asthma cases, whereas their presence in healthy subjects is at 28.1% and 2.4%, respectively (p for trend=0.0118). In detail, the CT genotype in MMP2 rs243845 was associated with a decreased asthma risk [adjusted odds ratio (OR)=0.57, 95% confidence interval (CI)=0.37-0.78, p=0.0040], and the T allele conferred a significantly lower asthma risk compared to the wild-type C allele (adjusted OR=0.55, 95%CI=0.43-0.77, p=0.0042). No significance was found for MMP2 rs2285053.
CONCLUSION
The genotype of CT in MMP2 rs243845 may serve as a novel biomarker in determining susceptibility to asthma in Taiwan.
背景/目的：据报道，基质金属蛋白酶 2（MMP2）在哮喘中过表达；然而，其基因型对哮喘的贡献尚未得到充分研究。因此，我们研究了 MMP2 基因型与台湾人群哮喘风险的关系。
材料和方法
在 198 例哮喘患者和 453 例非哮喘患者中，检测了 MMP2 -1306（rs243845）和-735（rs2285053）基因型。
结果
MMP2 rs243845 的 CT 和 TT 基因型在哮喘病例中的占比分别为 17.7%和 1.5%，而在健康受试者中的占比分别为 28.1%和 2.4%（趋势检验 p=0.0118）。具体而言，MMP2 rs243845 的 CT 基因型与哮喘风险降低相关[调整后的优势比（OR）=0.57，95%置信区间（CI）=0.37-0.78，p=0.0040]，T 等位基因与野生型 C 等位基因相比，哮喘风险显著降低（调整后的 OR=0.55，95%CI=0.43-0.77，p=0.0042）。MMP2 rs2285053 则无显著意义。
结论
MMP2 rs243845 的 CT 基因型可能成为确定台湾人群哮喘易感性的新型生物标志物。
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