Chen Xiao-Ling, Yuan Su-Xu, Chen Chen, Mao Yi-Xiang, Xu Gang, Wang Xian-Yuan
Department of Oncology, The First Affiliated Hospital, Soochow University, Suzhou, Jiangsu, 215006, P. R. China.
Ai Zheng. 2009 Dec;28(12):1328-32. doi: 10.5732/cjc.009.10245.
B7-H1, a member of B7 family, is expressed in tumor cells and has emerged as an important immune modulator capable of suppressing host immunity by inhibiting T cells function. This study was to probe into the correlation between the expression level of B7-H1 protein in pancreatic carcinoma tissues and clinicopathological characteristics and prognosis.
The expression of B7-H1 was measured in 40 cases of pancreatic carcinoma tissues and 10 cases of normal corresponding paracarcinoma tissues by immunohistochemistry. The relationship between the expression level of B7-H1 and clinicopathological characteristics and survival was analyzed.
The positive rate of B7-H1 was significantly higher in the tumor tissues [45.00% (18/40)] than in the normal corresponding paracarcinoma tissues [0(0/10)] (P<0.05); moreover, B7-H1 expression was significantly associated with the staging of tumor and preoperative serum CA19-9 level (P<0.05). The multivariate cox proportional hazards regression analysis of prognostic factors for overall survival and relapse-free survival showed that the expression of B7-H1 was an independent factor for poor prognosis.
B7-H1 protein was expressed in human pancreatic carcinoma tissues, and was associated with the prognosis.
B7-H1是B7家族成员之一，在肿瘤细胞中表达，已成为一种重要的免疫调节因子，能够通过抑制T细胞功能来抑制宿主免疫。本研究旨在探讨胰腺癌组织中B7-H1蛋白表达水平与临床病理特征及预后的相关性。
采用免疫组织化学法检测40例胰腺癌组织及10例相应癌旁正常组织中B7-H1的表达。分析B7-H1表达水平与临床病理特征及生存情况的关系。
肿瘤组织中B7-H1阳性率[45.00%（18/40）]显著高于相应癌旁正常组织[0（0/10）]（P<0.05）；此外，B7-H1表达与肿瘤分期及术前血清CA19-9水平显著相关（P<0.05）。对总生存和无复发生存的预后因素进行多因素Cox比例风险回归分析显示，B7-H1表达是预后不良的独立因素。
B7-H1蛋白在人胰腺癌组织中表达，并与预后相关。
