Department of Anaesthesiology, Intensive Care Medicine and Multidisciplinary Pain Centre, Ziekenhuis Oost-Limburg, Genk, Belgium.
Eur J Pain. 2010 May;14(5):473.e1-9. doi: 10.1016/j.ejpain.2009.09.006. Epub 2009 Dec 2.
Even in present day pain therapy, neuropathic pain remains a challenge for clinicians to treat and a challenge for researchers to investigate. Different animal models have been developed to mimic neuropathic pain. Neurotrophins such as nerve growth factor, brain-derived neurotrophic factor and neurotrophin 3 have been studied extensively in these models, yet few review articles concerning brain-derived neurotrophic factor have been published. This article reassesses the literature concerning brain-derived neurotrophic factor expression in the sciatic nerve chronic constriction injury model, the sciatic nerve transection model, the spinal nerve ligation model and the spinal nerve transection model and discusses differences in regulation of brain-derived neurotrophic factor between these models and their causality with neuropathic pain.
即使在当今的疼痛治疗中，神经病理性疼痛仍然是临床医生治疗的挑战，也是研究人员研究的挑战。已经开发出不同的动物模型来模拟神经病理性疼痛。神经营养因子，如神经生长因子、脑源性神经营养因子和神经营养素 3，在这些模型中得到了广泛研究，但关于脑源性神经营养因子的综述文章却很少发表。本文重新评估了关于坐骨神经慢性缩窄性损伤模型、坐骨神经横断模型、脊神经结扎模型和脊神经横断模型中脑源性神经营养因子表达的文献，并讨论了这些模型之间脑源性神经营养因子调节的差异及其与神经病理性疼痛的因果关系。
