Kashimoto S, Furuya A, Nonaka A, Oguchi T, Koshimizu M, Kumazawa T
Department of Anaesthesiology, Yamanashi Medical University, Japan.
Eur J Anaesthesiol. 1997 Jul;14(4):359-61. doi: 10.1046/j.1365-2346.1997.00092.x.
There are only limited data on sevoflurane minimum alveolar concentration (MAC) in rats. This study was designed to determine the minimum alveolar concentration value for sevoflurane in younger and older rats. Minimum alveolar concentration determination was performed in spontaneously breathing animals, 9-week-old rats (younger, n = 8) and more than 13-month-old rats (older, n = 8). Rats were instrumented with a silastic catheter in the abdominal aorta via the femoral artery to allow for arterial blood gas sampling. Subsequently, minimum alveolar concentration for sevoflurane was determined in 40 younger and 38 older rats. Minimum alveolar concentration for sevoflurane in younger rats was significantly higher than in the older rats (2.68 +/- 0.19 vs. 2.29 +/- 0.19, P < 0.001). Subgroup analysis indicated that minimum alveolar concentration for sevoflurane was not affected by the presence of an arterial catheter in the abdominal aorta (younger, 2.75 +/- 0.08 vs. 2.67 +/- 0.21; older, 2.23 +/- 0.19 vs. 2.30 +/- 0.18). Minimum alveolar concentration is profoundly affected by the age of the animal, but not by limited instrumentation.
关于七氟醚在大鼠中的最低肺泡浓度（MAC）的数据有限。本研究旨在确定七氟醚在年轻和老年大鼠中的最低肺泡浓度值。在自主呼吸的动物中进行最低肺泡浓度测定，9周龄大鼠（年轻组，n = 8）和13月龄以上大鼠（老年组，n = 8）。通过股动脉在大鼠腹主动脉中插入硅橡胶导管，以便采集动脉血气样本。随后，在40只年轻大鼠和38只老年大鼠中测定七氟醚的最低肺泡浓度。年轻大鼠中七氟醚的最低肺泡浓度显著高于老年大鼠（2.68±0.19对2.29±0.19，P < 0.001）。亚组分析表明，腹主动脉中存在动脉导管对七氟醚的最低肺泡浓度没有影响（年轻组，2.75±0.08对2.67±0.21；老年组，2.23±0.19对2.30±0.18）。最低肺泡浓度受动物年龄的显著影响，但不受有限的仪器设备影响。
