Wilson Dulaney A, Mohr Lawrence C, Frey G Donald, Lackland Daniel, Hoel David G
Medical University of South Carolina, Department of Biostatistics, Bioinformatics and Epidemiology, 135 Cannon Street, Charleston, SC 29425, USA.
Health Phys. 2010 Jan;98(1):42-52. doi: 10.1097/HP.0b013e3181b97318.
The Mayak Production Association (MPA) worker registry has shown evidence of plutonium-induced health effects. Workers were potentially exposed to plutonium nitrate [(239)Pu(NO(3))(4)] and plutonium dioxide ((239)PuO(2)). Studies of plutonium-induced health effects in animal models can complement human studies by providing more specific data than is possible in human observational studies. Lung, liver, and bone cancer mortality rate ratios in the MPA worker cohort were compared to those seen in beagle dogs, and models of the excess relative risk of lung, liver, and bone cancer mortality from the MPA worker cohort were applied to data from life-span studies of beagle dogs. The lung cancer mortality rate ratios in beagle dogs are similar to those seen in the MPA worker cohort. At cumulative doses less than 3 Gy, the liver cancer mortality rate ratios in the MPA worker cohort are statistically similar to those in beagle dogs. Bone cancer mortality only occurred in MPA workers with doses over 10 Gy. In dogs given (239)Pu, the adjusted excess relative risk of lung cancer mortality per Gy was 1.32 (95% CI 0.56-3.22). The liver cancer mortality adjusted excess relative risk per Gy was 55.3 (95% CI 23.0-133.1). The adjusted excess relative risk of bone cancer mortality per Gy(2) was 1,482 (95% CI 566.0-5686). Models of lung cancer mortality based on MPA worker data with additional covariates adequately described the beagle dog data, while the liver and bone cancer models were less successful.
玛雅克生产协会（MPA）工人登记册已显示出钚诱发健康影响的证据。工人们可能接触到硝酸钚[（239）Pu（NO（3））（4）]和二氧化钚（（239）PuO（2））。对动物模型中钚诱发健康影响的研究可以通过提供比人类观察性研究更具体的数据来补充人类研究。将MPA工人队列中的肺癌、肝癌和骨癌死亡率比值与比格犬的进行比较，并将MPA工人队列中肺癌、肝癌和骨癌死亡超额相对风险模型应用于比格犬寿命研究的数据。比格犬的肺癌死亡率比值与MPA工人队列中的相似。在累积剂量小于3 Gy时，MPA工人队列中的肝癌死亡率比值在统计学上与比格犬的相似。骨癌死亡仅发生在剂量超过10 Gy的MPA工人中。给狗注射（239）Pu后，每Gy肺癌死亡调整后的超额相对风险为1.32（95%置信区间0.56 - 3.22）。每Gy肝癌死亡调整后的超额相对风险为55.3（95%置信区间23.0 - 133.1）。每Gy（2）骨癌死亡调整后的超额相对风险为1482（95%置信区间566.0 - 5686）。基于MPA工人数据并带有额外协变量的肺癌死亡模型充分描述了比格犬的数据，而肝癌和骨癌模型则不太成功。
